Evidence map›Paper›PMID 35817627›Full record

ArticleACS applied materials & interfaces2022

Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and

Wenjing Guo, Huabin Gao, Hui Li, Songhan Ge, Fenfen Zhang, Liyuan Wang, Huijuan Shi, Anjia Han

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Advancements in Aptamer-Driven DNA Nanostructures for Precision Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. The evolving landscape of PCSK9 inhibition in cancer.European journal of pharmacology · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wenjing GuoDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Huabin GaoDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Hui LiDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Songhan GeDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Fenfen ZhangDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Liyuan WangDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Huijuan ShiDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Anjia HanDepartment of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.ORCID 0000-0003-3357-5348
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared with the traditional single therapy, nanomedicine has promoted a multimodal combination treatment for various carcinomas, especially the development of corresponding intelligent multifunctional biomaterials based on advanced DNA nanotechnology has great potential in cancer combination therapy. Herein, we describe a strategy to "backpack" aptamer PL1, which specifically binds to PD-L1 and

Indexed as

B7-H1 AntigenColorectal NeoplasmsAnimalsCell Line, TumorDNAFolic AcidMiceOligonucleotidesProgrammed Cell Death 1 ReceptorProprotein Convertase 9RNA, Small InterferingB7-H1 AntigenDNAFolic AcidOligonucleotidesPCSK9 protein, humanPcsk9 protein, mouseProgrammed Cell Death 1 ReceptorProprotein Convertase 9RNA, Small Interferingaptamer PL1colorectal cancerDNA tetrahedron nanoassemblyimmunocombination therapyPCSK9

Identifiers

PMID35817627
PMCPMC9305706
OpenAlexW4285042937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.