Evidence map›Paper›PMID 35817563›Full record

ArticleJournal of medical genetics2023

Decision-making and regret in patients with germline

Lauren A Gamble, Robert R C Grant, Sarah G Samaranayake, Grace-Ann Fasaye, Christopher Koh, Louis Korman, Bilal Asif, Theo Heller, Jonathan M Hernandez, Andrew M Blakely and 1 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of medical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03030404 (Hereditary Gastric Cancer Syndromes), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03030404 completednot on this map

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2017 to 2025Enrolled733ConditionsStomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Costs of Cancer Prevention: Physical and Psychosocial Sequelae of Risk-Reducing Total Gastrectomy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lauren A GambleNational Cancer Institute, Surgical Oncology Program, National Institutes of Health, Bethesda, Maryland, USA.
Robert R C GrantNational Cancer Institute, Surgical Oncology Program, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-1152-5959
Sarah G SamaranayakeNational Cancer Institute, Surgical Oncology Program, National Institutes of Health, Bethesda, Maryland, USA.
Grace-Ann FasayeNational Cancer Institute, Genetics Branch, National Institutes of Health, Bethesda, Maryland, USA.
Christopher KohNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Louis KormanNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Bilal AsifNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Theo HellerNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jonathan M HernandezNational Cancer Institute, Surgical Oncology Program, National Institutes of Health, Bethesda, Maryland, USA.
Andrew M BlakelyNational Cancer Institute, Surgical Oncology Program, National Institutes of Health, Bethesda, Maryland, USA.
Jeremy L DavisNational Cancer Institute, Surgical Oncology Program, National Institutes of Health, Bethesda, Maryland, USA jeremy.davis@nih.gov.
National Institutes of Health · US

Funding

Interrogating the molecular underpinnings of metastatic colonizationZIABC011759 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HERNANDEZ, JONATHAN · 2017 to 2025
$18.9M
Surgical Oncology Program Training ProgramZIEBC012097 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BLAKELY, ANDREW · 2022 to 2025
$17.3M
Evaluating outcomes for patients with primary-metastatic gastrointestinal cancerZIABC011861 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HERNANDEZ, JONATHAN · 2019 to 2025
$166k
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

introductionProphylactic total gastrectomy (PTG) can eliminate gastric cancer risk and is recommended in carriers of a germline

methodsIndividuals with germline

resultsDecision-making was assessed in 120 patients. PTG

conclusionThe decision to undergo PTG is influenced by family cancer history and surveillance endoscopy results. Regret is associated with surgical complications and pathological absence of cancer. Individual cancer-risk assessment is necessary to improve pre-operative counselling and inform the decision-making process. TRIAL REGISTRATION NUMBER: NCT03030404.

Indexed as

Stomach NeoplasmsAntigens, CDCadherinsEmotionsGastrectomyGenetic Predisposition to DiseaseGerm-Line MutationHumansMaleMiddle AgedAntigens, CDCadherinsCDH1 protein, humanclinical decision-makingdigestive system neoplasmsgenetic predisposition to diseasesurgical oncologysurgical procedures, operative

Identifiers

PMID35817563
PMCPMC10248794
OpenAlexW4285004728

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.