Evidence map›Paper›PMID 35817559›Full record

ReviewPractical neurology2022

Classical infratentorial superficial siderosis of the central nervous system: pathophysiology, clinical features and management.

Natallia Kharytaniuk, Peter Cowley, Parag Sayal, Perla Eleftheriou, Simon F Farmer, Edgar Chan, Doris-Eva Bamiou, David J Werring

Open access · greenAbstract readReview
In one paragraph

Review in Practical neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Spontaneous Intracranial Hypotension: A Tertiary Care Experience.Annals of Indian Academy of Neurology · 2026
    Article
  5. Article
  6. Review
  7. CSF-venous fistulae-An underrecognized cause of superficial siderosis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Natallia KharytaniukUCL Ear Institute, London, UK.ORCID http://orcid.org/0000-0001-5392-263X
Peter CowleyLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.
Parag SayalVictor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Perla EleftheriouRed Cell Haematology Department, University College Hospital, London, UK.
Simon F FarmerDepartment of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.
Edgar ChanDepartment of Neuropsychology, National Hospital for Neurology and Neurosurgery, London, UK.ORCID http://orcid.org/0000-0003-2312-683X
Doris-Eva BamiouUCL Ear Institute, London, UK.
David J WerringStroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK d.werring@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2074-1861
National Hospital for Neurology and Neurosurgery · GBUniversity of Ulster · GBUniversity College Hospital · GB

Funding

Department of Health IS-BRC-1215-20016
6 · The paper itself

Abstract

The term superficial siderosis (SS) is derived from the Greek word 'sideros', meaning iron. It includes two subtypes, distinguished by their anatomical distribution, causes and clinical features: 'classical' infratentorial SS (iSS, which sometimes also affects supratentorial regions) and cortical SS (cSS, which affects only supratentorial regions). This paper considers iSS, a potentially disabling disorder usually associated with very slow persistent or intermittent subarachnoid bleeding from a dural defect, and characterised by progressive hearing and vestibular impairment, ataxia, myelopathy and cognitive dysfunction. The causal dural defect-most often spinal but sometimes in the posterior fossa-typically follows trauma or neurosurgery occurring decades before diagnosis. Increasing recognition of iSS with paramagnetic-sensitive MRI is leading to an unmet clinical need. Given the diagnostic challenges and complex neurological impairments in iSS, we have developed a multidisciplinary approach involving key teams. We discuss pathophysiology, diagnosis and management of iSS, including a proposed clinical care pathway.

Indexed as

MRINEUROSURGERYSUPERFICIAL SIDEROSIS

Identifiers

PMID35817559
PMCPMC7614629
OpenAlexW4285005116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.