Evidence map›Paper›PMID 35817274›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2022

Association of Intra-individual Differences in Estimated GFR by Creatinine Versus Cystatin C With Incident Heart Failure.

Debbie C Chen, Michael G Shlipak, Rebecca Scherzer, Nisha Bansal, O Alison Potok, Dena E Rifkin, Joachim H Ix, Anthony N Muiru, Chi-Yuan Hsu, Michelle M Estrella

Open access · greenAbstract read
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Differential Effect of Hospitalization on Cystatin C- and Creatinine-Based Estimated GFR.Journal of the American Society of Nephrology : JASN · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. eGFRInternational journal of cardiology. Cardiovascular risk and prevention · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Debbie C ChenDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California; Kidney Health Research Collaborative with University of California, San Francisco VA Medical Center, San Francisco, California.
Michael G ShlipakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California; Kidney Health Research Collaborative with University of California, San Francisco VA Medical Center, San Francisco, California; Department of Medicine, San Francisco VA Medical Center, San Francisco, California.
Rebecca ScherzerKidney Health Research Collaborative with University of California, San Francisco VA Medical Center, San Francisco, California; Department of Medicine, San Francisco VA Medical Center, San Francisco, California.
Nisha BansalKidney Research Institute, Division of Nephrology, School of Medicine, University of Washington, Seattle, Washington; Department of Medicine, School of Medicine, University of Washington, Seattle, Washington.
O Alison PotokDivision of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, California; Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California.
Dena E RifkinDivision of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, California; Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California.
Joachim H IxDivision of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, California; Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California.
Anthony N MuiruDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California; Kidney Health Research Collaborative with University of California, San Francisco VA Medical Center, San Francisco, California.
Chi-Yuan HsuDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Michelle M EstrellaDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California; Kidney Health Research Collaborative with University of California, San Francisco VA Medical Center, San Francisco, California; Division of Nephrology, San Francisco VA Medical Center, San Francisco, California; Department of Medicine, San Francisco VA Medical Center, San Francisco, California. Electronic address: michelle.estrella@ucsf.edu.
San Francisco VA Medical Center · USUniversity of California, San Francisco · USVA San Diego Healthcare System · USUniversity of California, San Diego · USUniversity of Washington · US

Funding

Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
Acute kidney injury among patients with chronic kidney diseaseR01DK114014 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 2018 to 2021
$3.0M
Patient Oriented Research in Kidney DiseaseK24DK092291 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 2011 to 2020
$1.2M
SEARCH-CKD: The nature of chronic kidney disease and elevated blood pressure in sub-Saharan Africa.K23DK119562 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUIRU, ANTHONY N · 2021 to 2025
$1.0M
The Clinical Applications of the Difference in Estimated Glomerular Filtration Rate by Cystatin C vs. Creatinine (eGFRDiff)K23DK128604 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POTOK, OLIVIA ALISON · 2021 to 2025
$951k
Using predictive analytics to tailor care for patients with newly diagnosed type 2 diabetesR21DK130018 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GOPALAN, ANJALI · 2021 to 2022
$456k
Mentored research in the intersection of kidney and cardiovascular diseaseK26DK138333 · NIDDK · UNIVERSITY OF WASHINGTON · PI Nisha Bansal · 2023 to 2026
$440k
Personalizing Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Therapy in Chronic Kidney DiseaseF32DK130543 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, DEBBIE CATHERINE · 2021 to 2021
$89k
NIDDK NIH HHS F32 DK130543NIDDK NIH HHS K23 DK119562NIDDK NIH HHS K23 DK128604NIDDK NIH HHS K24 DK092291NIDDK NIH HHS K26 DK138333NIDDK NIH HHS R01 DK114014NIDDK NIH HHS R21 DK130018NIDDK NIH HHS U01 DK060902
6 · The paper itself

Abstract

RATIONALE &

objectiveLower estimated glomerular filtration rate (eGFR) is associated with heart failure (HF) risk. However, eGFR based on cystatin C (eGFR STUDY

designProspective cohort study. SETTING &

participants4,512 adults with CKD and without prevalent HF who enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study. EXPOSURE: Difference in GFR estimates (eGFR OUTCOME: Incident HF hospitalization. ANALYTICAL APPROACH: Fine-Gray proportional subhazards regression was used to investigate the associations of baseline, time-updated, and slope of eGFR

resultsOf 4,512 participants, one-third had eGFR LIMITATIONS: Entry into the CRIC Study was determined by eGFR

conclusionsAmong persons with CKD who have large differences between eGFR

Indexed as

Heart FailureRenal Insufficiency, ChronicAdultCreatinineCystatin CGlomerular Filtration RateHumansIndividualityProspective StudiesCreatinineCystatin CBiomarkercardiovascular risk stratificationchronic kidney disease (CKD)creatininecystatin CeGFR slopeestimated glomerular filtration rate (eGFR)filtration markerheart failure (HF)HF hospitalizationkidney functionmeasurement accuracy

Identifiers

PMID35817274
PMCPMC9691565
OpenAlexW4284994257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.