Evidence map›Paper›PMID 35817217›Full record

ArticleNeurobiology of disease2022

Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs.

Chrysanthy Ikonomidou, Sophie H Wang, Nicole A Fuhler, Shreya Larson, Saverio Capuano, Kevin R Brunner, Kristin Crosno, Heather A Simmons, Andres F Mejia, Kevin K Noguchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chrysanthy IkonomidouDepartment of Neurology, University of Wisconsin, School of Medicine, Madison, WI, USA. Electronic address: Ikonomidou@neurology.wisc.edu.
Sophie H WangDepartment of Psychiatry, Washington University, School of Medicine, St Louis, USA.
Nicole A FuhlerDepartment of Psychiatry, Washington University, School of Medicine, St Louis, USA.
Shreya LarsonWisconsin National Primate Research Center, Madison, WI, USA.
Saverio CapuanoWisconsin National Primate Research Center, Madison, WI, USA.
Kevin R BrunnerWisconsin National Primate Research Center, Madison, WI, USA.
Kristin CrosnoWisconsin National Primate Research Center, Madison, WI, USA.
Heather A SimmonsWisconsin National Primate Research Center, Madison, WI, USA.
Andres F MejiaWisconsin National Primate Research Center, Madison, WI, USA.
Kevin K NoguchiDepartment of Psychiatry, Washington University, School of Medicine, St Louis, USA.
Washington University in St. Louis · USUniversity of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI WOZNIAK, DAVID FRANCIS · 2015 to 2019
$7.1M
ANESTHESIA TOXICITY IN NEONATAL PRIMATE BRAINR01HD052664 · NICHD · WASHINGTON UNIVERSITY · PI NOGUCHI, KEVIN K · 2007 to 2016
$4.0M
HYPOTHERMIA TO PREVENT NEUROTOXIC SIDE EFFECTS OF PEDIATRIC DRUGSR01HD083001 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI IKONOMIDOU, HRISSANTHI · 2016 to 2019
$2.1M
NICHD NIH HHS P50 HD103525NICHD NIH HHS R01 HD052664NICHD NIH HHS R01 HD083001NICHD NIH HHS U54 HD087011NIH HHS P51 OD011106
6 · The paper itself

Abstract

Barbiturates and benzodiazepines are GABA

Indexed as

Brain InjuriesHypothermiaHypothermia, InducedAnimalsBrainHumansInfantInfant, NewbornLeadMacaca mulattaMidazolamPhenobarbitalSevofluraneLeadMidazolamPhenobarbitalSevofluraneAntiseizureApoptosisBarbiturateBenzodiazepineBrain injuryDevelopmentSedative

Identifiers

PMID35817217
PMCPMC9354232
OpenAlexW4284971575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.