Evidence map›Paper›PMID 35816619›Full record

ArticleRevista medica del Instituto Mexicano del Seguro Social2022

[Genetic variability in the association of multiple sclerosis and Epstein-Barr virus].

Gerardo Rivera-Silva

Abstract readEditorial
In one paragraph

Article in Revista medica del Instituto Mexicano del Seguro Social, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Gerardo Rivera-SilvaUniversidad de Monterrey, Escuela de Medicina, Departamento de Ciencias Básicas. Monterrey, Nuevo León, México.ORCID 0000-0003-2587-5914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis is a neurodegenerative and autoimmune disease of the central nervous system that mainly affects young people, especially women; its origin has been associated with infection caused by the Epstein-Barr virus. However, not all people who have suffered infection by this virus develop multiple sclerosis, so it would be important to know the role of genetic variability, especially the individual allelic variability of the human leukocyte antigen; as well as to determine the molecular mechanisms and the immunological links of the virus when it remains latent inside the B lymphocytes. Based on the above, it could be defined if the virus is a necessary condition to develop the disease or if there are other factors that need to be present, and thus be able to establish specific prevention and treatment strategies. But the most relevant thing is that the virus is a present condition to develop multiple sclerosis and is potentially preventable through the design of the respective vaccine.

Indexed as

Epstein-Barr Virus InfectionsMultiple SclerosisAdolescentCentral Nervous SystemFemaleHerpesvirus 4, HumanHumansB-LymphocytesEpstein-Barr VirusHLA AntigensMultiples Sclerosis

Identifiers

PMID35816619
PMCPMC10396045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.