ArticleBrain and behavior2022
Regional homogeneity of adolescents with high-functioning autism spectrum disorder and its association with symptom severity.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder.Molecular autism · 2024Pooled it
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- Sex Differences in Spatiotemporal Consistency and Effective Connectivity of the Precuneus in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- Mapping Resting-State Brain Functional Specialization to Neurotransmitter Profiles in Autism Spectrum Disorder.CNS neuroscience & therapeutics · 2025Article
- Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes.Nature communications · 2025Article
- Investigating Resting-State Brain Activity in Adolescents with High-Functioning Autism Spectrum Disorder: Linking Fractional Amplitude of Low-Frequency Fluctuation to Clinical Symptoms.Journal of autism and developmental disorders · 2025Article
- Effects of vitamin D on brain function in preschool children with autism spectrum disorder: a resting-state functional MRI study.BMC psychiatry · 2025Article
- Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder.BMC sports science, medicine & rehabilitation · 2024Article
- The abnormalities of brain function in females with primary insomnia: a resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Abnormal spontaneous brain activity in females with autism spectrum disorders.Frontiers in neuroscience · 2023Article
- Regional homogeneity of adolescents with high-functioning autism spectrum disorder and its association with symptom severity.Brain and behavior · 2022Article
- Predictors of functional ability in autism spectrum disorder: A scoping review.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePrevious studies have revealed abnormal regional homogeneity (ReHo) in individuals with autism spectrum disorder (ASD); however, there is little consistency across the findings within these studies, partly due to small sample size and great heterogeneity among participants between studies. Additionally, few studies have explored the association between ReHo aberrance and clinical symptoms in individuals with ASD.
methodsForty-eight adolescents with high-functioning ASD and 63 group-matched typically developing (TD) controls received functional magnetic resonance imaging at rest. Group-level analysis was performed to detect differences in ReHo between ASD and TD. Evaluation of symptom severity in individuals with ASD was based on the Autism Behavior Checklist (ABC). Voxel-wise correlation analysis was undergone to examine the correlations between the symptom severity and ReHo map in individuals with ASD within brain areas with ReHo abnormalities.
resultsCompared with the TD controls, individuals with ASD exhibited increased ReHo in the bilateral anterior cingulate cortex, left caudate, right posterior cerebellum (cerebellar tonsil), and bilateral brainstem and decreased ReHo in the left precentral gyrus, left inferior parietal lobule, bilateral postcentral gyrus, and right anterior cerebellum (culmen). The correlation analysis indicated that the ReHo value in the brainstem was negatively associated with the ABC total scores and the scores of Relating factor, respectively.
conclusionsOur findings indicated that widespread ReHo abnormalities occurred in ASD, shedding light on the underlying neurobiology of pathogenesis and symptomatology of ASD.
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