Evidence map›Paper›PMID 35816586›Full record

ArticlePsychological trauma : theory, research, practice and policy2023

The unique association of posttraumatic stress disorder with hypertension among veterans: A replication of Kibler et al. (2009) using Bayesian estimation and data from the United States-Veteran Microbiome Project.

Daniel J Reis, Alexander M Kaizer, Adam R Kinney, Nazanin H Bahraini, Jeri E Forster, Lisa A Brenner

Open access · hybridAbstract read
In one paragraph

Article in Psychological trauma : theory, research, practice and policy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Daniel J ReisVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center for Veteran Suicide Prevention.ORCID 0000-0001-7806-3819
Alexander M KaizerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus.ORCID 0000-0003-2334-5514
Adam R KinneyVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center for Veteran Suicide Prevention.ORCID 0000-0002-8852-7477
Nazanin H BahrainiVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center for Veteran Suicide Prevention.ORCID 0000-0002-8504-3901
Jeri E ForsterVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center for Veteran Suicide Prevention.ORCID 0000-0002-7955-9127
Lisa A BrennerVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center for Veteran Suicide Prevention.
Mental Illness Research, Education and Clinical Centers · USColorado School of Public Health · US

Funding

Statistical Methods and Adaptive Trial Designs for Cardiovascular Outcomes with Information SharingK01HL151754 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KAIZER, ALEXANDER MARK · 2021 to 2025
$742k
National Institutes of Health; National Heart, Lung, and Blood InstituteNHLBI NIH HHS K01 HL151754NIH HHSRocky Mountain Mental Illness Research, Education, and Clinical CenterState of ColoradoUS Department of DefenseUS Department of Veterans AffairsUS Department of Veterans Affairs; Office of Academic Affiliations; Advanced Fellowship Program in Mental Illness Research and Treatment
6 · The paper itself

Abstract

objectiveKibler et al. (2009) reported that hypertension was related to PTSD independent of depression. These two conditions have significant diagnostic overlap. The present study sought to conceptually replicate this work with a veteran sample, using Bayesian estimation to directly update past results, as well as examine symptom severity scores in relation to hypertension.

methodThis was a secondary analysis of data obtained from the United States-Veteran Microbiome Project. Lifetime diagnoses of PTSD and major depressive disorder (MDD) were obtained from a structured clinical interview and hypertension diagnoses were extracted from electronic medical records. PTSD and depressive symptom severity were obtained from self-report measures. Logistic regressions with Bayesian estimation were used to estimate the associations between hypertension and (a) psychiatric diagnostic history and (b) symptom severity scores.

resultsCompared with veterans without lifetime diagnoses of either disorder, the PTSD-only group was estimated to have a 29% increase in hypertension risk, and the PTSD + MDD group was estimated to have a 66% increase in hypertension risk. Additionally, higher levels of PTSD symptom severity were associated with a higher risk of hypertension.

conclusionPTSD diagnosis and symptom severity are uniquely associated with hypertension, independent of MDD or depressive symptom severity. These results support previous findings that PTSD might be a modifiable risk factor for the prevention and treatment of hypertension. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Indexed as

HypertensionMajor Depressive DisorderStress Disorders, Post-TraumaticVeteransBayes TheoremComorbidityHumansUnited States

Identifiers

PMID35816586
PMCPMC9976482
OpenAlexW4285037655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.