ArticleMagnetic resonance in medicine2022
Deuterium MRSI of tumor cell death in vivo following oral delivery of
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies.European radiology experimental · 2024Pooled it
- Deuterium metabolic imaging beyond the brain: mapping tissue metabolism across the body.Magma (New York, N.Y.) · 2026Review
- Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Early Detection of Chemotherapy-Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium (Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Oral intake of deuterated choline at clinical dose for metabolic imaging of brain tumors.Npj imaging · 2025Article
- Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy.NMR in biomedicine · 2025Article
- A pathway toward clinical translation of hyperpolarized [1,4-Magnetic resonance in medicine · 2025Article
- New Horizons in HyperpolarizedMolecular imaging and biology · 2024Article
- Repeatability of deuterium metabolic imaging of healthy volunteers at 3 T.European radiology experimental · 2024Observational
- Imaging cancer metabolism using magnetic resonance.Npj imaging · 2024Review
- Assessment of the sensitivity ofNMR in biomedicine · 2023Article
- Application and development of Deuterium Metabolic Imaging in tumor glucose metabolism: visualization of different metabolic pathways.Frontiers in oncology · 2023Review
- Deuterium MRSI of tumor cell death in vivo following oral delivery ofMagnetic resonance in medicine · 2022Article
- Monitoring Response to Treatment with Oral [2,3-Radiology. Imaging cancer · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThere is an unmet clinical need for direct and sensitive methods to detect cell death in vivo, especially with regard to monitoring tumor treatment response. We have shown previously that tumor cell death can be detected in vivo from
methodsMice with subcutaneously implanted EL4 tumors were fasted for 1 h before administration (200 μl) of [2,3-
resultsThe malate/fumarate signal ratio increased from 0.022 ± 0.03 before drug treatment to 0.12 ± 0.04 following treatment (p = 0.023, n = 4). Labeled malate was undetectable in spectroscopic images acquired before treatment and increased in the tumor area following treatment. The increase in the malate/fumarate signal ratio was similar to that observed previously following intravenous administration of labeled fumarate.
conclusionOrally administered [2,3-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.