Evidence map›Paper›PMID 35816482›Full record

ArticlePloS one2022

Bionic eye system mimicking microfluidic structure and intraocular pressure for glaucoma surgery training.

Toshiro Yamanaka, Tomonori Niino, Seiji Omata, Kanako Harada, Mamoru Mitsuishi, Koichiro Sugimoto, Takashi Ueta, Kiyohito Totsuka, Tomoyasu Shiraya, Fumiyuki Araki and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Toshiro YamanakaDepartment of Mechanical Engineering, School of Engineering, The University of Tokyo, Bunkyo, Tokyo, Japan.ORCID 0000-0001-6113-2849
Tomonori NiinoNIDEK Co., Ltd., Gamagori, Aichi, Japan.
Seiji OmataFaculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.
Kanako HaradaDepartment of Mechanical Engineering, School of Engineering, The University of Tokyo, Bunkyo, Tokyo, Japan.
Mamoru MitsuishiDepartment of Mechanical Engineering, School of Engineering, The University of Tokyo, Bunkyo, Tokyo, Japan.
Koichiro SugimotoDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
Takashi UetaDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
Kiyohito TotsukaDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
Tomoyasu ShirayaDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
Fumiyuki ArakiDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
Muneyuki TakaoDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
Makoto AiharaDepartment of Ophthalmology, School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.ORCID 0000-0001-6810-0583
Fumihito AraiDepartment of Mechanical Engineering, School of Engineering, The University of Tokyo, Bunkyo, Tokyo, Japan.
The University of Tokyo · JPKumamoto University · JPNidek (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among increasing eye diseases, glaucoma may hurt the optic nerves and lead to vision loss, the treatment of which is to reduce intraocular pressure (IOP). In this research, we introduce a new concept of the surgery simulator for Minimally Invasive Glaucoma Surgery (MIGS). The concept is comprised of an anterior eye model and a fluidic circulatory system. The model made of flexible material includes a channel like the Schlemm's canal (SC) and a membrane like the trabecular meshwork (TM) covering the SC. The system can monitor IOP in the model by a pressure sensor. In one of the MIGS procedures, the TM is cleaved to reduce the IOP. Using the simulator, ophthalmologists can practice the procedure and measure the IOP. First, considering the characteristics of human eyes, we defined requirements and target performances for the simulator. Next, we designed and manufactured the prototype. Using the prototype, we measured the IOP change before and after cleaving the TM. Finally, we demonstrated the availability by comparing experimental results and target performances. This simulator is also expected to be used for evaluations and developments of new MIGS instruments and ophthalmic surgery robots in addition to the surgical training of ophthalmologists.

Indexed as

GlaucomaVisual ProsthesisHumansIntraocular PressureMicrofluidicsTrabecular Meshwork

Identifiers

PMID35816482
PMCPMC9273099
OpenAlexW4285012049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.