ArticlePloS one2022
Increasing risk of mortality across the spectrum of aortic stenosis is independent of comorbidity & treatment: An international, parallel cohort study of 248,464 patients.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Moderate Aortic Valve Stenosis Is Associated With Increased Mortality Rate and Lifetime Loss: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 409 680 Patients.Journal of the American Heart Association · 2024Pooled it
- Increasing Left Ventricular Mass and Death in Men and Women Investigated With Echocardiography.Journal of the American Heart Association · 2025Article
- Clinical, Echocardiographic, and Socioeconomic Predictors of Progression and Outcomes in Patients With Moderate Aortic Stenosis.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Sodium-Glucose Cotransporter 2 Inhibitors in Aortic Stenosis: Toward a Comprehensive Cardiometabolic Approach.International journal of molecular sciences · 2025Review
- New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals.Journal of the American College of Cardiology · 2025Article
- Global distribution of prognostically significant pulmonary pressure indicative of pulmonary hypertension.Journal of global health · 2025Article
- Mortality associated with moderate and severe mitral regurgitation in 608 570 men and women undergoing echocardiography.Heart (British Cardiac Society) · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Detection of severe aortic stenosis by clinicians versus artificial intelligence: A retrospective clinical cohort study.American heart journal plus : cardiology research and practice · 2024Article
- Machine Learning Prediction for Prognosis of Patients With Aortic Stenosis.JACC. Advances · 2024Article
- An Artificial Intelligence Algorithm for Detection of Severe Aortic Stenosis: A Clinical Cohort Study.JACC. Advances · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Asymptomatic Severe and Moderate Aortic Stenosis: Time for Appraisal of Treatment Indications.Structural heart : the journal of the Heart Team · 2023Review
- Enhanced detection of severe aortic stenosis via artificial intelligence: a clinical cohort study.Open heart · 2023Article
- Comorbidities and Symptom Status in Moderate and Severe Aortic Stenosis: A Multicenter Clinical Cohort Study.JACC. Advances · 2023Article
- Asymptomatic Aortic Stenosis in an Older Patient: How the Geriatric Approach Can Make a Difference.Diagnostics (Basel, Switzerland) · 2023Article
- Risk for Mortality with Increasingly Severe Aortic Stenosis: An International Cohort Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023Article
- Counting the cost of premature mortality with progressively worse aortic stenosis in Australia: a clinical cohort study.The lancet. Healthy longevity · 2022Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile large scientific and medical evidence has demonstrated the increased risk of death and cardiovascular mortality in patients with severe AS, the independent contribution of moderate AS to an increased risk of death remains uncertain. METHODS AND
findingsWe conducted a multicenter study including a cohort of 30,865 US patients and another cohort of 217,599 Australian patients with equivalent echocardiographic and aortic valve profiling over the same period (2003-2017). During a median 5.2 years (US) and 4.4 years (Australian) follow-up, the risk of death (hazard ratio) of patients with moderate AS as compared to those without AS was 1.66 (95%CI 1.52-1.80) and 1.37 (95%CI 1.34-1.41) in the US and Australian cohorts, even after adjusting this analysis for age and sex. This increased risk of death and cardiovascular mortality (odds ratio) in patients with moderate AS was consistent also across subgroups of left ventricular ejection fraction (LVEF) (subgroups of LVEF < 40%, 40-49%, 50-59%, and ≥ 60%: OR of moderate AS for CV mortality 2.0 [95%CI 1.4-2.7], 1.7 [95%CI 1.2-2.4], 1.5 [95%CI 1.1-1.9], and 1.4 [95%CI 1.2-1.6], respectively).
conclusionsThe findings of this study suggest that patients with moderate AS have a potential increased risk of death and cardiovascular mortality, regardless of age, sex, and LVEF. Hence, these data suggest the need to develop specific strategies to detect and treat individuals with moderate AS.
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