Trial reportPloS one2022
The unified protocol as an internet-based intervention for emotional disorders: Randomized controlled trial.
Trial report in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Measurement Properties of the Patient Health Questionnaire-15 and Somatic Symptom Scale-8: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Pooled it
- A systematic review and meta-analysis of transdiagnostic cognitive behavioural therapies for emotional disorders.Nature human behaviour · 2024Pooled it
- Trial
- Pilot Randomized Controlled Trial of the Emotion Detectives In-Out: A Blended Version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children.Child psychiatry and human development · 2026Article
- Unified protocol in online group versus blended format for treating emotional disorders in university students: Preliminary results on feasibility at 6-month follow-up.Psychology and psychotherapy · 2026Article
- Accelerated Unified Protocol for Transdiagnostic Treatment of Anxiety Disorders in a VHA System.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2026Article
- Usability and Acceptance by Therapists and Users of an Internet-Based Intervention Based on the Unified Protocol in Argentina.Journal of clinical psychology · 2025Article
- Work-focused therapy in an internet-based CBT format - A mixed methods feasibility study.Internet interventions · 2025Article
- Unified Protocol for Emotional Disorders in University Students: Protocol for a Randomized Trial of Online and Blended Formats.International journal of methods in psychiatric research · 2025Article
- Article
- Factors Associated with Prospective Acceptability and Preferences for Unified Transdiagnostic Cognitive-Behavioral Treatments and Group Therapy in the Portuguese General Population.Administration and policy in mental health · 2024Article
- TONI - One for all? Participatory development of a transtheoretic and transdiagnostic online intervention for blended care.Internet interventions · 2024Article
- Effects of internet-based, psychosocial, and early medical interventions on professional burnout in health care workers: Systematic literature review and meta-analysis.Internet interventions · 2023Review
- Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Group Format in Spain: Results of a Noninferiority Randomized Controlled Trial at 15 Months after Treatment Onset.Depression and anxiety · 2023Article
- Differential Effects of Psychological Interventions in Online and Face-to-Face Settings on DSM-5 and ICD-11 Maladaptive Trait Domains: An Exploratory Pilot Study.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Unified Protocol (UP) as a transdiagnostic intervention has primarily been applied in the treatment of anxiety disorders and in face-to-face-settings. The current study investigated the efficacy of a 10-week Internet-based adaptation of the UP for anxiety, depressive, and somatic symptom disorders. The trial was registered under DRKS00014820 at the German Clinical Trial Registry, DRKS. Participants (n = 129) were randomized to treatment or waitlist control. Significant treatment effects were found for symptom distress, satisfaction with life, positive/negative affect and markers of anxiety, depression, and somatic symptom burden (within-group Hedges' g = 0.32-1.38 and between-group g = 0.20-1.11). Treatment gains were maintained at 1- and 6-month-follow-up. Subgroup analyses showed comparable effects in participants with anxiety and depressive disorders. 26.6% dropped out of treatment and 35.38% did not provide post-treatment assessments. The results strengthen the application of the UP as an Internet-based treatment for alleviating symptom distress across emotional disorders. More research on the applicability for single disorders is needed and avenues to improve adherence and attrition rates should be explored.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.