ArticleJournal of applied clinical medical physics2022
Impact of beam-hardening corrections on proton relative stopping power estimates from single- and dual-energy CT.
Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 5 citations in OpenAlex.
- Impact of beam hardening on proton stopping-power ratio estimation using photon-counting, dual-energy, and single-energy computed tomography.Physics and imaging in radiation oncology · 2026Article
- Longitudinal CT number characterization of a novel upright CT for proton therapy planning.Journal of applied clinical medical physics · 2026Article
- Reduction of CT number location dependency using photon-counting detector CT and virtual monoenergetic imaging.Physics in medicine and biology · 2026Article
- Dual-energy CT for proton therapy: Impact of advanced slice-wise patient-thickness estimation methods for improved stopping-power prediction.Journal of applied clinical medical physics · 2026Article
- Effects of various tilt angles on radiation dose and image quality in pediatric head computed tomography: A phantom study.Journal of applied clinical medical physics · 2025Article
- Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators.Journal of applied clinical medical physics · 2023Article
- Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- Impact of beam-hardening corrections on proton relative stopping power estimates from single- and dual-energy CT.Journal of applied clinical medical physics · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major contributing factor to proton range uncertainty is the conversion of computed tomography (CT) Hounsfield units (HU) to proton relative stopping power (RSP). This uncertainty is heightened in the presence of X-ray beam-hardening artifact (BHA), which has two manifestations: cupping and streaking, especially in and near bone tissue. This uncertainty can affect the accuracy of proton RSP calculation for treatment planning in proton radiotherapy. Dual-energy CT (DECT) and iterative beam-hardening correction (iBHC) both show promise in mitigating CT BHA. This present work attempts to analyze the relative robustness of iBHC and DECT techniques on both manifestations of BHA. The stoichiometric method for HU to RSP conversion was used for single-energy CT (SECT) and DECT-based monochromatic techniques using a tissue substitute phantom. Cupping BHA was simulated by measuring the HU of a bone substitute plug in wax/3D-printed phantoms of increasing size. Streaking BHA was simulated by placing a solid water plug between two bone plugs in a wax phantom. Finally, the effect of varying calibration phantom size on RSP was calculated in an anthropomorphic head phantom. The RSP decreased -0.002 cm
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