ArticleAmerican journal of respiratory and critical care medicine2022
Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of
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In one paragraph
Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Transcriptomics of interstitial lung disease: a systematic review and meta-analysis.The European respiratory journal · 2025Pooled it
- Causal and shared genetic insights into severe COVID-19 and idiopathic pulmonary fibrosis.iScience · 2026Article
- Genes, other than Muc5b, are associated with bleomycin-induced lung injury.Communications biology · 2026Article
- SYISL promotes pulmonary epithelial-mesenchymal transition and fibrosis through DSP-Hippo/YAP pathway.Cellular and molecular life sciences : CMLS · 2026Article
- Ectopic expression of MUC5B in the respiratory bronchiole initiates endoplasmic reticulum stress in the IPF lung.American journal of respiratory cell and molecular biology · 2026Article
- Expanding role of cell-free DNA for the early diagnosis and monitoring of pulmonary diseases.Chinese medical journal · 2026Review
- Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis.Communications biology · 2026Article
- The role of histone methylation in fibrosis and its therapeutic potential.Journal of translational medicine · 2026Review
- A regulatory network underlying idiopathic pulmonary fibrosis.Frontiers in immunology · 2026Article
- Multi-omics approaches in idiopathic pulmonary fibrosis: from molecular mechanisms to therapeutic targets and precision medicine.Frontiers in pharmacology · 2026Review
- Pathway information on methylation analysis using deep neural network (PROMINENT): An interpretable deep learning method with pathway prior for phenotype prediction using gene-level DNA methylation.Artificial intelligence in medicine · 2025Article
- Photoperiodic responsiveness in the DNA methylation and gene expression in the hypothalamus of ovariectomized and estradiol-treated ewes.BMC genomics · 2025Article
- Identifying potential drug targets for tourette syndrome: a Mendelian randomization study based on druggable genes.Italian journal of pediatrics · 2025Article
- Role of Epigenetics in Chronic Lung Disease.Cells · 2025Review
- Article
- An Overview of the Role of Genetic factors in Idiopathic Pulmonary Fibrosis: Insights from Epidemiology to Prognosis.International journal of medical sciences · 2025Review
- Association of theFrontiers in genetics · 2025Article
- Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model.Molecular medicine (Cambridge, Mass.) · 2024Article
- MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.Clinical epigenetics · 2024Article
- Review
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 3 countries.
Raphael BorieUniversité Paris Diderot, Paris, France.ORCID 0000-0002-9906-0024
Jonathan CardwellDepartment of Medicine.
Iain R KonigsbergDepartment of Medicine.ORCID 0000-0001-7356-100X
Camille M MooreDepartment of Biostatistics and Bioinformatics and.
Weiming ZhangDepartment of Biostatistics and Bioinformatics and.
Sarah K SasseDepartment of Medicine, and.
Fabienne GallyDepartment of Medicine.
Evgenia DobrinskikhDepartment of Medicine.
Avram WaltsDepartment of Medicine.
Julie PowersDepartment of Medicine.
Janna BrancatoDepartment of Medicine.
Mauricio RojasDepartment of Internal Medicine, Ohio State College of Medicine, The Ohio State University, Columbus, Ohio.
Paul J WoltersDepartment of Medicine, University of California, San Francisco, California.
Kevin K BrownDepartment of Medicine, and.
Timothy S BlackwellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Tomoko NakanishiDepartment of Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Canada.ORCID 0000-0001-9510-5646
J Brent RichardsDepartment of Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Canada.ORCID 0000-0002-3746-9086
Anthony N GerberDepartment of Medicine.
Tasha E FingerlinDepartment of Biostatistics and Bioinformatics and.
Norman SachsCell Biology, Vertex Pharmaceuticals, San Diego, California; and.
Sara L PulitComputational Genomics, Vertex Pharmaceuticals, Boston, Massachusetts.
Zachary ZappalaComputational Genomics, Vertex Pharmaceuticals, Boston, Massachusetts.
David A SchwartzDepartment of Medicine.
Ivana V YangDepartment of Medicine.
National Jewish Health · USVertex Pharmaceuticals (United States) · USJewish General Hospital · CAColorado School of Public Health · USDélégation Paris 7 · FRPediatrics and Genetics · USThe Ohio State University · USUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USVanderbilt University Medical Center · US
Funding
Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6MRole of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4MPreclinical Pulmonary Fibrosis, an opportune rare disease cohortUH3HL151865 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2022 to 2025
$4.3MRole of FABP5 in COPD ExacerbationsR01HL141264 · NHLBI · NATIONAL JEWISH HEALTH · PI Fabienne Gally · 2019 to 2026
$3.7MMolecular Determinants of Usual Interstitial Pneumonia (UIP)R01HL158668 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David Albert Schwartz, Ivana V Yang · 2022 to 2026
$3.5MGenes and Transcripts that Interact with MUC5B in Pulmonary FibrosisR01HL149836 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CLOUTHIER, DAVID E., SCHWARTZ, DAVID ALBERT · 2020 to 2023
$3.0MBLRD VA I01 BX005295NHLBI NIH HHS P01 HL092870NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R01 HL141264NHLBI NIH HHS R01 HL149836NHLBI NIH HHS R01 HL158668NHLBI NIH HHS UH3 HL151865
Abstract
PubMed holds no abstract for this paper.
Indexed as
Idiopathic Pulmonary FibrosisDesmoplakinsDNADNA MethylationGene ExpressionGenetic Predisposition to DiseaseHumansMucin-5BQuantitative Trait LociRNADesmoplakinsDNADSP protein, humanMUC5B protein, humanMucin-5BRNAcommon genetic variantepigenomefunctional genomicspulmonary fibrosistranscriptome
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.