Evidence map›Paper›PMID 35816252›Full record

ArticleCellular and molecular life sciences : CMLS2022

Siah2-GRP78 interaction regulates ROS and provides a proliferative advantage to Helicobacter pylori-infected gastric epithelial cancer cells.

Pragyesh Dixit, Swathi Shivaram Suratkal, Shrikant Babanrao Kokate, Debashish Chakraborty, Indrajit Poirah, Supriya Samal, Niranjan Rout, Shivaram P Singh, Arup Sarkar, Asima Bhattacharyya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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  9. Frontiers in medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Pragyesh DixitSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India.
Swathi Shivaram SuratkalSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India.
Shrikant Babanrao KokateSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India.
Debashish ChakrabortySchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India.
Indrajit PoirahSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India.
Supriya SamalSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India.
Niranjan RoutDepartment of Pathology, Acharya Harihar Post Graduate Institute of Cancer, Cuttack, Odisha, 753007, India.
Shivaram P SinghDepartment of Gastroenterology, SCB Medical College, Cuttack, Odisha, 753007, India.
Arup SarkarTrident Academy of Creative Technology, Bhubaneswar, Odisha, 751024, India.
Asima BhattacharyyaSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda, Jatni, Odisha, 752050, India. asima@niser.ac.in.ORCID http://orcid.org/0000-0001-7292-6644
National Institute of Science Education and Research · INSriram Chandra Bhanja Medical College Hospital · INUniversity of Helsinki · FI

Funding

Science and Engineering Research Board SB/SO/BB-0015/2014
6 · The paper itself

Abstract

Helicobacter pylori-mediated gastric carcinogenesis involves upregulation of the E3 ubiquitin ligase Siah2 and its phosphorylation-mediated stabilization. This study elucidates a novel mechanism of oxidative stress regulation by phosphorylated Siah2 in H. pylori-infected gastric epithelial cancer cells (GECs). We identify that H. pylori-mediated Siah2 phosphorylation at the 6th serine residue (P-S

Indexed as

Helicobacter InfectionsHelicobacter pyloriStomach NeoplasmsEndoplasmic Reticulum Chaperone BiPEpithelial CellsGastric MucosaHumansReactive Oxygen SpeciesUbiquitin-Protein LigasesEndoplasmic Reticulum Chaperone BiPReactive Oxygen SpeciesUbiquitin-Protein LigasesAggresomeAutophagosomeBiP/GRP78E3 ubiquitin ligaseOxidative stressSiah

Identifiers

PMID35816252
PMCPMC11072387
OpenAlexW4285042650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.