ArticleeLife2022
The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- A simple analytical model for Neanderthal disappearance due to genetic dilution by recurrent small-scale immigrations of modern humans.Scientific reports · 2025Article
- TheScience (New York, N.Y.) · 2025Article
- Dentition of the Mugharet El'Aliya Fossil Human Maxilla, Morocco.American journal of biological anthropology · 2025Article
- Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025Review
- Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years.Science (New York, N.Y.) · 2024Article
- The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal.Nature communications · 2024Article
- More than a decade of genetic research on the Denisovans.Nature reviews. Genetics · 2024Review
- Human genetic adaptation related to cellular zinc homeostasis.PLoS genetics · 2023Article
- A global catalog of whole-genome diversity from 233 primate species.Science (New York, N.Y.) · 2023Article
- Production method of the Königsaue birch tar documents cumulative culture in Neanderthals.Archaeological and anthropological sciences · 2023Article
- Evolution of Homo in the Middle and Late Pleistocene.Journal of human evolution · 2022Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Proteins associated with the spindle apparatus, a cytoskeletal structure that ensures the proper segregation of chromosomes during cell division, experienced an unusual number of amino acid substitutions in modern humans after the split from the ancestors of Neandertals and Denisovans. Here, we analyze the history of these substitutions and show that some of the genes in which they occur may have been targets of positive selection. We also find that the two changes in the kinetochore scaffold 1 (KNL1) protein, previously believed to be specific to modern humans, were present in some Neandertals. We show that the
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