Evidence map›Paper›PMID 35815804›Full record

ReviewJournal of natural products2022

Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.

Devadoss J Samuvel, Nga T Nguyen, Hartmut Jaeschke, John J Lemasters, Xiaojuan Wang, Yeun-Mun Choo, Mark T Hamann, Zhi Zhong

Open access · greenAbstract readReview
In one paragraph

Review in Journal of natural products, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Animal models accurately representing acute liver failure (Review).International journal of molecular medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Nutrients · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Devadoss J SamuvelDrug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
Nga T NguyenDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, United States.
Hartmut JaeschkeDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, United States.ORCID 0000-0002-8695-6980
John J LemastersDrug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
Xiaojuan WangSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, People's Republic of China.
Yeun-Mun ChooChemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Mark T HamannDrug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
Zhi ZhongDrug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
Medical University of South Carolina · USUniversity of Kansas Medical Center · USLanzhou University · CNUniversity of Malaya · MY

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2009 to 2026
$42.7M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Evan R Delgado · 2020 to 2026
$18.7M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Garth R Swanson · 2020 to 2026
$8.8M
Mitochondrial depolarization, mitophagy, and mitochondrial DAMPs in ALDR01AA025379 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ZHI ZHONG · 2018 to 2026
$3.8M
Mechanisms of Mitochondrial Iron Uptake: New Therapeutic Targets in HepatotoxicityR01DK119523 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J, NIEMINEN, ANNA-LIISA · 2021 to 2024
$1.8M
Confocal/Multiphoton Microscope UpgradeS10OD018113 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2015 to 2015
$570k
NCI NIH HHS P30 CA138313NIAAA NIH HHS R01 AA025379NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK119523NIGMS NIH HHS P20 GM130457NIH HHS S10 OD018113
6 · The paper itself

Abstract

Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryAnimalsDrug CombinationsGlycosidesKelch-Like ECH-Associated Protein 1LiverMiceMice, Inbred C57BLNecrosisNF-E2-Related Factor 2Oxidative StressPhenolsAcetaminophenDrug CombinationsGlycosidesKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Phenolsplatanoside

Identifiers

PMID35815804
PMCPMC9788857
OpenAlexW4284990231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.