Evidence map›Paper›PMID 35815624›Full record

ArticleHand (New York, N.Y.)2024

Conduit/Wrap Repairs to Digital Nerves Provide Residual Strength After Peak Loading.

Grace E Tavitas, Patrick J Schimoler, Alexander Kharlamov, Peter Tang, Mark Carl Miller

Open access · greenAbstract read
In one paragraph

Article in Hand (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Grace E TavitasSaint Vincent College, Latrobe, PA, USA.
Patrick J SchimolerAllegheny Health Network, Pittsburgh, PA, USA.
Alexander KharlamovAllegheny Health Network, Pittsburgh, PA, USA.
Peter TangAllegheny Health Network, Pittsburgh, PA, USA.
Mark Carl MillerUniversity of Pittsburgh, PA, USA.ORCID 0000-0002-4902-3452
Allegheny Health Network · USSaint Vincent College · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany techniques are used for digital nerve repair, most commonly coaptation by sutures. Nerve repairs must be strong while offering an environment for nerve regeneration. Sutures can damage the nerve and thereby limit growth and regeneration. Sutures can rip and cause sudden catastrophic failure. Fibrin glue and conduit-wraps allow a good environment for growth, but neither provides much strength. A benefit to conduit repair would arise if the repair maintained integrity after the peak load so that the path for regrowth stayed in place. The goal for this study was to determine whether conduit with glue provides continued strength after a maximum load is reached.

methodsDigital cadaveric nerves were harvested and repaired with 2 epineurial sutures, conduit, and fibrin glue in all combinations. Tests to failure were performed, gap displacement between nerve ends recorded, and the postpeak load energy to dissociation of the nerve and conduit was calculated.

resultsConduit with glue and 2 sutures at the end had the greatest energy and displacement after the peak load but was not significantly different than conduit with glue and 1 suture. Conduit with glue alone obtained statistically the same displacement as conduit with glue and 2 sutures. Conduit, with or without glue, and 2 sutures was statistically the same as suture only repair for peak load.

conclusionConduit/wrap maintains a load capacity and a path for nerve regeneration after the peak. Suture at the ends of conduit, not at the coaptation site, reduces damage at the point of injury.

Indexed as

Fibrin Tissue AdhesivePeripheral NervesHumansNerve RegenerationNeurosurgical ProceduresFibrin Tissue Adhesiveanatomyarthritisbasic sciencebiomechanicsdiagnosishandnervenerve injurynerve reconstructionnerve regenerationpost traumatic

Identifiers

PMID35815624
PMCPMC10953519
OpenAlexW4284968790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.