Evidence map›Paper›PMID 35815403›Full record

ArticleNutrition and cancer2023

Genome-Wide Association Study of Metachronous Colorectal Adenoma Risk among Participants in the Selenium Trial.

Mario Jesus Trejo, Ken Batai, Yuliang Chen, Stefanie Brezina, H-H Sherry Chow, Nathan Ellis, Peter Lance, Chiu-Hsieh Hsu, Kristen Pogreba-Brown, Maria Bishop and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nutrition and cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Mario Jesus TrejoDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.
Ken BataiDepartment of Urology, University of Arizona, Tucson, AZ, USA.
Yuliang ChenDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.
Stefanie BrezinaCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
H-H Sherry ChowUniversity of Arizona Cancer Center, Tucson, AZ, USA.
Nathan EllisDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Peter LanceUniversity of Arizona Cancer Center, Tucson, AZ, USA.
Chiu-Hsieh HsuDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-7451-4018
Kristen Pogreba-BrownDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.
Maria BishopDepartment of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA.
Andrea GsurCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Elizabeth T JacobsDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.
University of Arizona · USComprehensive Cancer Center Vienna · AT

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
WHEAT BRAN FIBER SUPPLEMENTS ON THE RECURRENCE OF COLONIC ADENOMASP01CA041108 · NCI · UNIVERSITY OF ARIZONA · PI LANCE, M. PETER · 1986 to 2009
$38.8M
Selenium Colorectal Cancer Chemoprevention TrialsR01CA151708 · NCI · UNIVERSITY OF ARIZONA · PI JACOBS, ELIZABETH T · 2011 to 2021
$6.8M
University of Arizona's Initiative for Maximizing Student Development (IMSD)T32GM139779 · NIGMS · UNIVERSITY OF ARIZONA · PI FRANS E TAX · 2022 to 2026
$2.9M
NCI NIH HHS P01 CA041108NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA151708NIGMS NIH HHS T32 GM139779
6 · The paper itself

Abstract

Genetic variants related to colorectal adenoma may help identify those who are at highest risk of colorectal cancer development or illuminate potential chemopreventive strategies. The purpose of this genome-wide association study was to identify genetic variants that are associated with risk of developing a metachronous colorectal adenoma among 1,215 study participants of European descent from the Selenium Trial. Associations of variants were assessed with logistic regression analyses and validated in an independent case-control study population of 1,491 participants from the Colorectal Cancer Study of Austria (CORSA). No statistically significant genome-wide associations between any variant and metachronous adenoma were identified after correction for multiple comparisons. However, an intron variant of

Indexed as

AdenomaColorectal NeoplasmsSeleniumCase-Control StudiesColonoscopyGenome-Wide Association StudyHumansRisk FactorsSelenium

Identifiers

PMID35815403
PMCPMC10120393
OpenAlexW4284990073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.