ArticleJournal of thrombosis and haemostasis : JTH2022
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study.
Article in Journal of thrombosis and haemostasis : JTH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Global Research Hotspots and Trends in Obesity-Related Venous Thromboembolism (2000-2025): a Bibliometric Analysis.Obesity surgery · 2026Article
- Identification of key risk factors for venous thromboembolism in urological inpatients based on the Caprini scale and interpretable machine learning methods.Thrombosis journal · 2024Article
- Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study.Research and practice in thrombosis and haemostasis · 2024Article
- SGLT2 inhibition, venous thrombolism, and death due to cardiac causes: a mediation Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- The interaction effect of transfusion history and previous stroke history on the risk of venous thromboembolism in stroke patients: a prospective cohort study.Thrombosis journal · 2023Article
- Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study.Journal of thrombosis and haemostasis : JTH · 2022Article
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9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated.
aimTo study the joint effect of MI and obesity on the risk of VTE.
methodsStudy participants (n = 29 410) were recruited from three surveys of the Tromsø Study (conducted in 1994-1995, 2001, and 2007-2008) and followed up through 2014. All incident MI and VTE cases during follow-up were recorded. Cox regression models with MI as a time-dependent variable were used to estimate hazard ratios (HRs) of VTE (adjusted for age and sex) by combinations of MI exposure and obesity status. Joint effects were assessed by calculating relative excess risk and attributable proportion (AP) due to interaction.
resultsDuring a median of 19.6 years of follow-up, 2090 study participants experienced an MI and 784 experienced a VTE. Among those with MI, 55 developed a subsequent VTE, yielding an overall incidence rate (IR) of VTE of 5.3 per 1000 person-years (95% confidence interval [CI]: 4.1-6.9). In the combined exposure group (MI+/Obesity+), the IR was 11.3 per 1000 person-years, and the adjusted HR indicated a 3-fold increased risk of VTE (HR 3.16, 95% CI: 1.99-4.99) compared to the reference group (MI-/Obesity-). The corresponding AP was 0.46 (95% CI: 0.17-0.74).
conclusionsThe combination of MI and obesity yielded a supra-additive effect on VTE risk of which 46% of the VTE events were attributed to the interaction.
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