ReviewCardiac failure review2022
In-hospital Initiation and Up-titration of Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction.
Review in Cardiac failure review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Empagliflozin after myocardial infarction with or without diabetes and chronic kidney disease: Insights from EMPACT-MI.ESC heart failure · 2025Trial
- Heart failure burden and care among cardiology inpatients: insights from the Hellenic Cardiorenal Morbidity Snapshot (HECMOS) study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Gaps in Guideline-Directed Medical Therapy for Heart Failure: A Cross-Sectional Study in an Underserved Population.Cureus · 2026Article
- Article
- Assessment of Pharmacotherapy Modifications During the Treatment of Episodes of Acutely Decompensated Heart Failure: The HEROES Study.Journal of clinical medicine · 2025Article
- SGLT2-is in Acute Heart Failure.Journal of clinical medicine · 2025Review
- Society for Maternal-Fetal Medicine Consult Series #73: Diagnosis and management of right and left heart failure during pregnancy and postpartum.Pregnancy (Hoboken, N.J.) · 2025Article
- Article
- Guideline-directed medical therapy implementation during hospitalization for cardiogenic shock.ESC heart failure · 2025Article
- Comprehensive Benefits of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Reduced Ejection Fraction: A Literature Review.Journal of clinical medicine research · 2024Review
- Statin therapy impact on Long-Term outcomes in acute heart Failure: Retrospective analysis of hospitalized patients.International journal of cardiology. Heart & vasculature · 2024Article
- Role of vericiguat in management of patients with heart failure with reduced ejection fraction after worsening episode.ESC heart failure · 2024Review
- Myocardial Recovery in the Systemic Context: A Philosophic Shift for the Heart Failure Subspecialty to Optimize Patient Care.Methodist DeBakey cardiovascular journal · 2024Review
- Hospitalist Recognition and Treatment of Obesity in Inpatients: A Quality Improvement Cohort Study.Journal of Brown hospital medicine · 2024Article
- Summary and Comparison of the 2022 ACC/AHA/HFSA and 2021 ESC Heart Failure Guidelines.Cardiology and therapy · 2023Review
- Guideline-Directed Medical Therapy for the Treatment of Heart Failure with Reduced Ejection Fraction.Drugs · 2023Review
- Acute heart failure: differential diagnosis and treatment.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implementation of guideline-directed medical therapy for patients with heart failure is suboptimal. The use of guideline-directed medical therapy improves minimally after heart failure hospitalisation, despite this event clearly indicating increased risk of further hospitalisation and death. In-hospital initiation and titration of guideline-directed medical therapies is one potential strategy to fill these gaps in care, both in the acute vulnerable period after hospital discharge and in the long term. The purpose of this article is to review the knowledge gaps in best practices of in-hospital initiation and up-titration of guideline-directed medical therapies, the benefits and risks of in-hospital initiation and post-discharge focused titration of guideline-directed medical therapies, the recent literature evaluating these practices, and propose strategies to apply these principles to the care of patients with heart failure with reduced ejection fraction.
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Registered trials
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