ArticleBioinformation2022
Safety and physiologic effects of intranasal midazolam and nitrous oxide inhalation based sedation in children visiting Saveetha Dental College and Hospitals, India.
Article in Bioinformation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- A Cross-Sectional Study on Knowledge, Attitude, and Practice of Tooth-Supported Complete Overdenture Among Middle-Aged and Elderly People: A Structural Equation Modeling Analysis.Patient preference and adherence · 2026Article
- Physiological and psychomotor effectiveness of rapid and slow induction of nitrous oxide inhalation sedation in pediatric patients undergoing dental procedures: a randomized clinical study.Journal of dental anesthesia and pain medicine · 2025Article
- Procedural sedation competencies: a review and multidisciplinary international consensus statement on knowledge, skills, training, and credentialing.British journal of anaesthesia · 2025Review
- Article
- Pharmacologic Sedation-Related Respiratory Complications in Pediatric Dentistry: A Decade-Long Scoping Review.Iranian journal of pharmaceutical research : IJPRReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large number of patients avoid dental care due to anxiety. Various techniques are available for behaviour related management. Therefore, safety and physiologic effects of intranasal midazolam and nitrous oxide inhalation based sedation in children aged 4 to 8 years visiting Saveetha Dental College and Hospitals, India is of interest. 35 anxious patients aged 4 to 8 years were included in the study. The patient received either intranasal midazolam/nitrous oxide in the first visit and vice versa at the second visit. The onset of sedation, recovery time and procedure duration were recorded using a timer. Physiological parameters were recorded using a monitor. Safety scale was used for assessing prevalence of adverse reactions. There was no significant difference between the groups in safety scale scores, recovery time and procedure duration. Midazolam group showed a statistically significant faster onset of sedation and a statistically significant increase in heart rate at four recorded time-points. All the vitals were within the physiological limits. Thus, intranasal midazolamis a safe alternative to nitrous-oxide sedation in completing the intended dental treatment while managing the anxious children in dental clinic.
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Registered trials
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