ArticleJournal of asthma and allergy2022
Prevalence of Patients with Uncontrolled Asthma Despite NVL/GINA Step 4/5 Treatment in Germany.
Article in Journal of asthma and allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Machine learning for prediction of asthma exacerbations among asthmatic patients: a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Between Guidelines and Daily Practice: The Persistent Use of Parenteral Depot Corticosteroids in Germany.Clinical and translational allergy · 2026Article
- [Care for uncontrolled asthma in Germany - with focus on Magdeburg and Mannheim regions].Deutsche medizinische Wochenschrift (1946) · 2026Article
- Medical Unmet Needs in Uncontrolled Asthma Despite GINA Step 4/5 Treatment in Poland.Journal of asthma and allergy · 2026Article
- Criteria for evaluation of response to biologics in severe asthma - the Biologics Asthma Response Score (BARS).Pneumologie (Stuttgart, Germany) · 2025Article
- Unmet needs of patients with COPD in Germany: a retrospective, cross-sectional study.ERJ open research · 2025Article
- Maintenance OCS Were Used More Frequently Than Biologics in Patients with Uncontrolled GINA 4/5 Asthma in Germany in 2019.Journal of asthma and allergy · 2024Article
- [Criteria for evaluation of response to biologics in severe asthma - the Biologics Asthma Response Score (BARS)].Pneumologie (Stuttgart, Germany) · 2023Article
- Health Care Situation in the Treatment of Uncontrolled GINA Step 4/5 Patients in Germany.Journal of asthma and allergy · 2023Article
Corrections and comments
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Authors and funding
10 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Asthma is one of the most prevalent chronic diseases in Germany affecting 4-5% of all adults and 10% of children. Despite the availability of biologicals in recent years, studies show patients with inadequately controlled severe asthma in real life. The aim of the current study was to characterize and estimate the number of patients with NVL/GINA level 4 or 5 asthma and signs of poor control in Germany. Patients and Methods: In 2021, we retrospectively analyzed data collected during 2019 using the IQVIA™ LRx and IQVIA™ Disease Analyzer databases which contain anonymized longitudinal data covering approximately 80% of statutory health insurance (GKV) prescriptions in Germany with most relevant information about prescriptions, basic patient demographics or location of the prescriber; the IQVIA™ Disease Analyzer anonymized electronic medical records from a representative sample of office-based GPs and specialists. An expert committee of pulmonologists from different hospitals and expert practices supported the study. Asthma patients treated according to NVL/GINA 4/5 who used SABAs frequently (≥3 on days with no ICS-containing prescriptions/year) and/or received prescriptions for oral corticosteroids (OCS) (score of ≥2/year, a pulmonologist prescription scored 1.0, GP 0.75) were classified as severe, uncontrolled asthma. Results: In 2019, 3.4 million patients received at least two prescriptions of respiratory medications and 2.4 million patients on maintenance respiratory treatment have asthma. A total of 625,000 asthma patients were treated according to NVL/GINA step 4 or 5. Among these, 54,000 were uncontrolled according to the pre-defined OCS and/or SABA use, which corresponds to approximately 15% of patients in certain regions. Conclusion: In 2019, approximately 54,000 patients in Germany treated according to NVL/GINA step 4/5 had evidence suggestive for poor asthma control, up to 15% of patients in certain regions. Yet, only 12,000 patients overall were being treated with biologicals suggesting a possible treatment gap that requires further investigation.
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