ArticleFrontiers in psychiatry2022
Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 22 citations in OpenAlex.
- Association of triglyceride-glucose index with anxiety in first-episode, drug-naïve major depressive disorder: role of subclinical hypothyroidism.European archives of psychiatry and clinical neuroscience · 2026Article
- Prevalence of thyroid dysfunction in psychiatric inpatients: A cross sectional prevalence study.Bioinformation · 2026Article
- Prevalence and Clinical Correlates of Anxiety in Chinese Outpatient Population with Somatic Symptom Disorder.Neuropsychiatric disease and treatment · 2026Article
- Neurological consequences of adult-onset hypothyroidism.Endocrine journal · 2025Review
- Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset.European archives of psychiatry and clinical neuroscience · 2025Article
- Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks.BMC medicine · 2025Article
- Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value.Scientific reports · 2025Article
- Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-naïve major depressive disorder.BMC psychiatry · 2025Article
- The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Non-linear relationship between TSH and psychotic symptoms on first episode and drug naïve major depressive disorder patients: a large sample sized cross-sectional study in China.BMC psychiatry · 2024Article
- Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study.Brain and behavior · 2024Article
- Integrative effects of transcutaneous auricular vagus nerve stimulation on esophageal motility and pharyngeal symptoms via vagal mechanisms in patients with laryngopharyngeal reflux disease.Frontiers in neuroscience · 2024Article
- Correlation Between Anxiety and Serum Thyroid Hormone Levels in Patients With Papillary Thyroid Carcinoma Undergoing Microwave Ablation.Depression and anxiety · 2024Article
- Clinical characteristics of suicidal behavior in first hospitalization and drug-naïve patients with major depressive disorder.Annals of general psychiatry · 2023Article
- Pituitary crosstalk with bone, adipose tissue and brain.Nature reviews. Endocrinology · 2023Review
- Article
- Prevalence and Factors Associated with Subclinical Hypothyroidism in Major Depressive Disorder Patients with Dyslipidemia.Neuropsychiatric disease and treatment · 2023Article
- Thyroid function, renal function, and depression: an association study.Frontiers in psychiatry · 2023Article
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Backgrounds: Subclinical hypothyroidism (SCH) was reported to be associated with depression; however, its role in coexisting anxiety symptom in young patients with major depressive disorder (MDD) remains unclear. The objective of this study was to explore the relationship between SCH and anxiety symptom in young first-episode and drug-naïve (FEDN) MDD patients. Methods: A total of 520 outpatients diagnosed as FEDN MDD with SCH were recruited in this study. Their socio-demographic, clinical data and thyroid function parameters were collected. The Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD) were employed to measure the severity of anxiety symptom and depressive symptom, respectively. Based on the HAMA scores, patients who scored ≥ 25 were defined as anxious major depressive disorder (A-MDD) while others as non-anxious major depressive disorder (NA-MDD). Results: The prevalence rate of A-MDD was 15.8% in young FEDN MDD patients with comorbid SCH. Moreover, serum thyroid stimulating hormone (TSH) levels were significantly higher in patients with A-MDD compared with those with NA-MDD ( Conclusions: A-MDD patients presented higher serum TSH level. It is suggested that serum TSH level may be a potential biomarker for predicting moderate and severe anxiety symptoms in young FEDN MDD patients with SCH.
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