ArticleStatistics and its interface2022
Pathway Lasso: Pathway Estimation and Selection with High-Dimensional Mediators.
Article in Statistics and its interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Bayesian Image Mediation Analysis.Journal of the American Statistical Association · 2026Article
- Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026Article
- BHMnet: Bayesian high-dimensional mediation analysis with network information integration for correlated mediators.Briefings in bioinformatics · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting.Biostatistics (Oxford, England) · 2025Article
- Mediation analysis with graph mediator.Biostatistics (Oxford, England) · 2025Article
- High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics application.Bioinformatics (Oxford, England) · 2025Article
- Causal mediation analysis: selection with asymptotically valid inference.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- Debiased machine learning for ultra-high dimensional mediation analysis.Bioinformatics (Oxford, England) · 2025Article
- Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD.bioRxiv : the preprint server for biology · 2025Article
- Mediation CNN (Med-CNN) Model for High-Dimensional Mediation Data.International journal of molecular sciences · 2025Article
- MULTIVARIATE DYNAMIC MEDIATION ANALYSIS UNDER A REINFORCEMENT LEARNING FRAMEWORK.Annals of statistics · 2025Article
- A novel strategy for detecting multiple mediators in high-dimensional mediation models.Frontiers in psychiatry · 2025Article
- A Bayesian high-dimensional mediation analysis for multilevel genome-wide epigenetic data.Journal of applied statistics · 2025Article
- Mediation Analysis with Multiple Exposures and Multiple Mediators.Statistics in medicine · 2024Article
- Speeding up interval estimation forbioRxiv : the preprint server for biology · 2024Article
- Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease.Environment international · 2024Article
- Network-Assisted Mediation Analysis with High-Dimensional Neuroimaging Mediators.Proceedings of machine learning research · 2024Article
- Methods for the Analysis of Multiple Epigenomic Mediators in Environmental Epidemiology.Current environmental health reports · 2024Review
- EEG functional connectivity as a Riemannian mediator: An application to malnutrition and cognition.Human brain mapping · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In many scientific studies, it becomes increasingly important to delineate the pathways through a large number of mediators, such as genetic and brain mediators. Structural equation modeling (SEM) is a popular technique to estimate the pathway effects, commonly expressed as the product of coefficients. However, it becomes unstable and computationally challenging to fit such models with high-dimensional mediators. This paper proposes a sparse mediation model using a regularized SEM approach, where sparsity means that a small number of mediators have a nonzero mediation effect between a treatment and an outcome. To address the model selection challenge, we innovate by introducing a new penalty called
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.