Evidence map›Paper›PMID 35814841›Full record

ArticleThe Saudi dental journal2022

The impact of tobacco smoking and electronic cigarette vaping on salivary biomarkers. A comparative study.

Naglaa M Kamal, Noha S Shams

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Saudi dental journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. E-cigarette: a safe tool or a risk factor for oral cancer? A systematic review.Journal of clinical and experimental dentistry · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Naglaa M KamalDepartment of Oral Pathology, Faculty of Oral and Dental Medicine, Ahram Canadian University, 6th of October, Egypt.
Noha S ShamsDepartment of Oral Pathology, Faculty of Oral and Dental Medicine, Ahram Canadian University, 6th of October, Egypt.
Ahram Canadian University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to investigate the effect of electronic cigarette vaping and cigarette smoking on the levels of interleukin-1β and transforming growth factor‑β salivary biomarkers compared to non-smokers. Methods: One hundred and fifty people participated in this study; There were 50 participants who smoked traditional cigarettes, 50 who used electronic cigarettes, and 50 healthy people who had never smoked cigarettes (control group). Furthermore, 5 ml of unstimulated whole saliva was sampled and clarified by centrifugation and frozen until analysis. Interleukin-1β and transforming growth factor‑β concentrations were assessed in saliva samples using ELISA. The duplicate readings average was utilized to interpret the data. Results: We found that cigarette smokers had significantly higher levels of interleukin-1β and transforming growth factor‑β than non-smokers and electronic cigarette users (p < 0.05). The difference between control participants and electronic cigarette users, as well as that between control participants and traditional cigarette smokers, was statistically significant (p < 0.05). Conclusion: Electronic cigarette users have higher levels of inflammatory and cancer risk biomarker than non-smokers, suggesting that electronic cigarettes can pose a risk of developing systemic diseases but less than conventional cigarettes. In conclusion, our study could be regarded as new evidence supporting the hazardous effects of e-cigs using a cost-effective, non-invasive method.

Indexed as

BiomarkerCytokineInflammationVaping

Identifiers

PMID35814841
PMCPMC9263753
OpenAlexW4280508438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.