Evidence map›Paper›PMID 35814779›Full record

ReviewFrontiers in medicine2022

Novel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target.

Maomao Wu, Yanxun Han, Xiangfei Gong, Ke Wan, Yuchen Liu, Yi Zhou, Lizhi Zhang, Guozheng Tang, Hui Fang, Bangjie Chen and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Maomao WuDepartment of Pharmacy, Anhui Chest Hospital, Hefei, China.
Yanxun HanDepartment of Otolaryngology - Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiangfei GongWannan Medical College, Wuhu, China.
Ke WanSchool of Pharmacy, Anhui Medical University, Hefei, China.
Yuchen LiuDepartment of Otolaryngology - Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yi ZhouThe First Clinical Medical College, Anhui Medical University, Hefei, China.
Lizhi ZhangThe First Clinical Medical College, Anhui Medical University, Hefei, China.
Guozheng TangThe First Clinical Medical College, Anhui Medical University, Hefei, China.
Hui FangDepartment of Pharmacy, Hangzhou Normal University Affiliated Hospital, Hangzhou, China.
Bangjie ChenThe First Clinical Medical College, Anhui Medical University, Hefei, China.
Fan YangThe First Clinical Medical College, Anhui Medical University, Hefei, China.
Qing ZhaoDepartment of Pharmacy, Hangzhou Normal University Affiliated Hospital, Hangzhou, China.
Genbao WangDepartment of Pharmacy, Hangzhou Normal University Affiliated Hospital, Hangzhou, China.
Chenghao ZhanghuangDepartment of Urology, Kunming Children's Hospital, Kunming, China.
Yunling ZhangDepartment of Pharmacy, Anhui Chest Hospital, Hefei, China.
Anhui Medical University · CNAffiliated Hospital of Hangzhou Normal University · CNFirst Affiliated Hospital of Anhui Medical University · CNXi'an Chest Hospital · CNKunming Children's Hospital · CNWannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer (CC) is a prominent cancer around the globe, with a high incidence, and fatality rate. Numerous recent investigations have shown that various non-coding RNAs are associated with the progression of CC. Circular RNAs, a novel class of non-coding RNAs, have a single chain covalent closed-loop structure and are involved in cell growth and other physiological processes. These dysregulated circRNAs seem to have environment-specific functions. They have been demonstrated in certain studies to have a dual involvement in oncogene production and tumor inhibition in different cell settings. Simultaneously, some evidence indicates that circRNAs are abnormally expressed in CC and contributes to its progression. Thus, the distinctive expression profile of circRNAs is associated with the diagnosis, prognosis, and treatment outcomes of CC. We summarized numerous CC-specific circles and their function in revealing the molecular processes of carcinogenesis and progression in CC in this review. Taken together, these data suggest that circRNA may be used as an early detection biomarker and potential therapeutic target in patients with CC.

Indexed as

cervical cancercircRNAHCCmechanismphysiological functions

Identifiers

PMID35814779
PMCPMC9260044
OpenAlexW4283327750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.