Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology.
Ahmed Abdelhak, Isaac Solomon, Shivany Condor Montes, Alexandra Saias, Christian Cordano, Breton Asken, Corrina Fonseca, Frederike Cosima Oertel, Konstantinos Arfanakis, Adam M Staffaroni and 5 more
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 3 institutions in 1 country.
Ahmed AbdelhakWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.ORCID https://orcid.org/0000-0001-9731-4169
Isaac SolomonSan Diego School of Medicine University of California, San Diego La Jolla California USA.
Shivany Condor MontesWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Alexandra SaiasWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Christian CordanoWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Breton AskenWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Corrina FonsecaWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Frederike Cosima OertelWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering Illinois Institute of Technology Chicago Illinois USA.
Adam M StaffaroniWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Joel H KramerWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Michael GeschwindWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Bruce L MillerWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Fanny M ElahiWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
Ari J GreenWeill Institute for Neurosciences Department of Neurology University of California at San Francisco (UCSF) San Francisco California USA.
University of California, San Francisco · USRush University Medical Center · USUniversity of California San Diego · US
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Predicting progression of human prion diseaseR01AG031189 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2008 to 2017
$5.7M
Tracking longitudinal change in presymptomatic genetic prion disease (TLC-Pre-gPrD)R01AG062562 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2019 to 2023
$5.4M
TLC-Pre-gPrD: Tracking Longitudinal Change in Presymptomatic genetic Prion DiseaseR56AG055619 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2018 to 2018
Introduction: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non-invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. Methods: Results: MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging-based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). Discussion: I-bRAVO is a rapid, non-invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD.
Indexed as
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathycerebral small vessel diseaseretinal vesselsvascular dementiawhite matter disease
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology. · full record | OpenQuestion