Evidence map›Paper›PMID 35814521›Full record

ArticleJournal of clinical and experimental hepatology

Quantitative Ultrasound Assessment of Hepatic Steatosis.

Artem Kaliaev, Wilson Chavez, Jorge Soto, Fahimul Huda, Hua Xie, Man Nguyen, Vijay Shamdasani, Stephan Anderson

Abstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Artem KaliaevBoston University Medical Center, Department of Radiology, Boston, MA, USA.
Wilson ChavezBoston University Medical Center, Department of Radiology, Boston, MA, USA.
Jorge SotoBoston University Medical Center, Department of Radiology, Boston, MA, USA.
Fahimul HudaBoston University Medical Center, Department of Radiology, Boston, MA, USA.
Hua XieUltrasound Imaging and Interventions, Philips Research North America, Cambridge, MA, USA.
Man NguyenUltrasound Imaging and Interventions, Philips Research North America, Cambridge, MA, USA.
Vijay ShamdasaniPhilips Healthcare, Bothell, WA, USA.
Stephan AndersonBoston University Medical Center, Department of Radiology, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is widespread chronic disease of the live in humans with the prevalence of 30% of the United States population. Methods: This prospective study enrolled a total of 31 patients with clinical suspicion of NAFLD to receive liver fat measurements by quantitative ultrasound and reference MRI measurements (proton density fat-fraction, PDFF). The following ultrasound (US) parameters based on both raw ultrasound RF (Radio Frequency) data and 2D B-mode images of the liver were analyzed with subsequent correlation with MRI-PDFF: hepatorenal index, acoustic attenuation coefficient, Nakagami coefficient parameter, shear wave viscosity, shear wave dispersion and shear wave elasticity. Ultrasound parameters were also correlated with the presence of hypertension and diabetes. Results: The mean (± SD) age and body mass index of the patients were 49.03 (± 12.49) and 30.12 (± 6.15), respectively. Of the aforementioned ultrasound parameters, the hepatorenal index and acoustic attenuation coefficient showed a strong correlation with MRI-PDFF derivations of hepatic steatosis, with Conclusions: Hepatorenal index and acoustic attenuation coefficient correlate well with MRI-PDFF-derived measurements of hepatic steatosis. Quantitative ultrasound is a promising tool for the diagnosis and assessment of patients with NAFLD.

Indexed as

ALT, alanine aminotransferaseAST, aspartate aminotransferaseBMI, body mass indexDICOM, digital imaging and communications in medicineHgb A1C, hemoglobin A1C (glycated hemoglobin)HIPAA, health insurance portability and accountability actHRI, hepatorenal indexIQ, in-phase quadratureIR, insulin resistanceLDL, low-density lipoproteinliver fat quantificationMRI-PDFF, magnetic resonance imaging - proton density fat-fractionNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisnon-alcoholic fatty liver diseaseRF, raw radio frequencyROI, regions of interestSD, standard deviationT2DM, type 2 diabetes mellitusultrasoundUS, ultrasound

Identifiers

PMID35814521
PMCPMC9257875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.