Evidence map›Paper›PMID 35814460›Full record

ArticleFrontiers in oncology2022

Intra- and Peritumoral Radiomics Model Based on Early DCE-MRI for Preoperative Prediction of Molecular Subtypes in Invasive Ductal Breast Carcinoma: A Multitask Machine Learning Study.

Shuhai Zhang, Xiaolei Wang, Zhao Yang, Yun Zhu, Nannan Zhao, Yang Li, Jie He, Haitao Sun, Zongyu Xie

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shuhai ZhangDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Xiaolei WangDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Zhao YangDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Yun ZhuDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Nannan ZhaoDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Yang LiDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Jie HeDepartment of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Haitao SunDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zongyu XieDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
First Affiliated Hospital of Bengbu Medical College · CNZhejiang University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The aim of this study is to investigate radiomics features extracted from the optimal peritumoral region and the intratumoral area on the early phase of dynamic contrast-enhanced MRI (DCE-MRI) for predicting molecular subtypes of invasive ductal breast carcinoma (IDBC). Methods: A total of 422 IDBC patients with immunohistochemical and fluorescence Results: A 6-mm peritumoral size was defined the optimal peritumoral region in classification tasks of hormone receptor (HR)-positive vs others, triple-negative breast cancer (TNBC) vs others, and HR-positive vs human epidermal growth factor receptor 2 (HER2)-enriched vs TNBC, and 8 mm was applied in HER2-enriched vs others. The combined clinical-radiological and radiomics models in three binary classification tasks (HR-positive vs others, HER2-enriched vs others, TNBC vs others) obtained optimal performance with AUCs of 0.838, 0.848, and 0.930 in the training cohort, respectively; 0.827, 0.813, and 0.879 in the internal test cohort, respectively; and 0.791, 0.707, and 0.852 in the external test cohort, respectively. Conclusion: Radiomics features in the intratumoral and peritumoral regions of IDBC on DCE-MRI had a potential to predict the HR-positive, HER2-enriched, and TNBC molecular subtypes preoperatively.

Indexed as

breast cancerdynamic contrast-enhanced imagingmagnetic resonance imagingmolecular subtyperadiomics

Identifiers

PMID35814460
PMCPMC9263840
OpenAlexW4283362360

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.