Evidence map›Paper›PMID 35814260›Full record

ArticlePhysics and imaging in radiation oncology2022

Impact of magnetic resonance-guided versus conventional radiotherapy workflows on organ at risk doses in stereotactic body radiotherapy for lymph node oligometastases.

Anita M Werensteijn-Honingh, Petra S Kroon, Dennis Winkel, J Carlijn van Gaal, Jochem Hes, Louk M W Snoeren, Jaleesa K Timmer, Christiaan C P Mout, Gijsbert H Bol, Alexis N Kotte and 4 more

Open access · goldAbstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Anita M Werensteijn-HoninghDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Petra S KroonDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Dennis WinkelDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
J Carlijn van GaalDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Jochem HesDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Louk M W SnoerenDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Jaleesa K TimmerDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Christiaan C P MoutDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Gijsbert H BolDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Alexis N KotteDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Wietse S C EppingaDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Martijn IntvenDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Bas W RaaymakersDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Ina M Jürgenliemk-SchulzDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
University Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Magnetic resonance (MR)-linac delivery is expected to improve organ at risk (OAR) sparing. In this study, OAR doses were compared for online adaptive MR-linac treatments and conventional cone beam computed tomography (CBCT)-linac radiotherapy, taking into account differences in clinical workflows, especially longer session times for MR-linac delivery. Materials and methods: For 25 patients with pelvic/abdominal lymph node oligometastases, OAR doses were calculated for clinical pre-treatment and daily optimized 1.5 T MR-linac treatment plans (5 × 7 Gy) and compared with simulated CBCT-linac plans for the pre-treatment and online anatomical situation. Bowelbag and duodenum were re-contoured on MR-imaging acquired before, during and after each treatment session. OAR hard constraint violations, D Results: Overall, hard constraints for all OAR were violated less often in daily online MR-linac treatment plans compared with CBCT-linac: in 5% versus 22% of fractions, respectively. D Conclusions: Compared with CBCT-linac treatments, the online adaptive MR-linac approach resulted in fewer hard planning constraint violations compared with single-plan CBCT-linac delivery. With respect to other bowelbag/duodenum dose-volume parameters, the longer duration of MR-linac treatment sessions negatively impacts the potential dosimetric benefit of daily adaptive treatment planning.

Indexed as

BowelCBCT-linacDuodenumLymph node metastasesMR-linacStereotactic body radiotherapy

Identifiers

PMID35814260
PMCPMC9263510
OpenAlexW4283736039

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.