ArticlePhysics and imaging in radiation oncology2022
Knowledge-based automatic plan optimization for left-sided whole breast tomotherapy.
Article in Physics and imaging in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06317948 (Improving the Quality of Radiotherapy by Multi-Institution Knowledge-Based Planning Optimization Models), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving the Quality of Radiotherapy by Multi-Institution Knowledge-Based Planning Optimization Models
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Implementation and Dosimetric Evaluation of a Knowledge-Based IMRT Model for Left-Sided Breast Radiotherapy with DIBH.Journal of applied clinical medical physics · 2026Article
- Automated fluence optimization in breast cancer radiotherapy: balancing dosimetric quality, organ-at-risk sparing, and workflow efficiency.Radiation oncology (London, England) · 2026Article
- The smoothing factor in breast intensity-modulated radiotherapy: dosimetric impact and a predictive model of plan acceptability.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Article
- Effectiveness of multi-criteria optimization in combination with knowledge-based modeling in radiotherapy of left-sided breast including regional nodes.Physics and imaging in radiation oncology · 2024Article
- Evaluation of Ethos intelligent optimization engine for left locally advanced breast cancer.Frontiers in oncology · 2024Article
- Fully automated volumetric modulated arc therapy technique for radiation therapy of locally advanced breast cancer.Radiation oncology (London, England) · 2023Article
- Evaluation of a clinically introduced deep learning model for radiotherapy treatment planning of breast cancer.Physics and imaging in radiation oncology · 2023Article
- Clinical implementation of deep learning-based automated left breast simultaneous integrated boost radiotherapy treatment planning.Physics and imaging in radiation oncology · 2023Article
- Towards real-time radiotherapy planning: The role of autonomous treatment strategies.Physics and imaging in radiation oncology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Purpose: Tomotherapy may deliver high-quality whole breast irradiation at static angles. The aim of this study was to implement Knowledge-Based (KB) automatic planning for left-sided whole breast using this modality. Materials/Methods: Virtual volumetric plans were associated to the dose distributions of 69 Tomotherapy (TT) clinical plans of previously treated patients, aiming to train a KB-model using a commercial tool completely implemented in our treatment planning system. An individually optimized template based on the resulting KB-model was generated for automatic plan optimization. Thirty patients of the training set and ten new patients were considered for internal/external validation. Fully-automatic plans (KB-TT) were generated and compared using the same geometry/number of fields of the corresponding clinical plans. Results: KB-TT plans were successfully generated in 26/30 and 10/10 patients of the internal/external validation sets; for 4 patients whose original plans used only two fields, the manual insertion of one/two fields before running the automatic template was sufficient to obtain acceptable plans. Concerning internal validation, planning target volume V Conclusion: Automatic TT left-sided breast KB-plans are comparable to or slightly better than clinical plans and can be obtained with limited planner time. The approach is currently under clinical implementation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.