ArticleJournal of Raman spectroscopy : JRS2021
Lipid profiling using Raman and a modified support vector machine algorithm.
Article in Journal of Raman spectroscopy : JRS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Raman spectroscopy and machine learning for early detection of gastric cancer and Helicobacter pylori with gastric juice.Scientific reports · 2025Article
- The Raman Map of the Human Cell.Analytical chemistry · 2025Article
- Label-free plasmonic spectral profiling of serum DNA.Biosensors & bioelectronics · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Lipid droplets are dynamic organelles that play important cellular roles. They are composed of a phospholipid membrane and a core of triglycerides and sterol esters. Fatty acids have important roles in phospholipid membrane formation, signaling, and synthesis of triglycerides as energy storage. Better non-invasive tools for profiling and measuring cellular lipids are needed. Here we demonstrate the potential of Raman spectroscopy to determine with high accuracy the composition changes of the fatty acids and cholesterol found in the lipid droplets of prostate cancer cells treated with various fatty acids. The methodology uses a modified least squares fitting (LSF) routine that uses highly discriminatory wavenumbers between the fatty acids present in the sample using a support vector machine algorithm. Using this new LSF routine, Raman micro-spectroscopy can become a better non-invasive tool for profiling and measuring fatty acids and cholesterol for cancer biology.
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Registered trials
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