ArticleFrontiers in bioengineering and biotechnology2022
Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 31 citations in OpenAlex.
- Aortic Longitudinal Stretch and Recoil Affect Cerebral Perfusion: Insights from a Physiologically Accurate In-Vitro Experiment Model.Annals of biomedical engineering · 2026Article
- Patient-Specific Aortic Growth Prediction in Type B Aortic Dissection Using Finite-Element Simulation Based on the Unified Fiber Distribution (UFD) Model.Annals of biomedical engineering · 2026Article
- Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling.Advanced healthcare materials · 2026Review
- Aortic and cardiovascular remodelling after thoracic endovascular aortic repair for blunt traumatic aortic injury in younger patients: A narrative review of physiological and clinical outcomes.Experimental physiology · 2026Review
- Impact of Residual Intimal Flap Displacement Post-TEVAR on TBAD Haemodynamics in Compliant, Patient-specific CFD Simulations Informed by MRI.Annals of biomedical engineering · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Aortic stretch and recoil create wave-pumping effect: the second heart in the systemic circulation.Journal of the Royal Society, Interface · 2025Article
- The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2024Article
- A preoperative planning procedure of septal myectomy for hypertrophic obstructive cardiomyopathy using image-based computational fluid dynamics simulations and shape optimization.Scientific reports · 2024Article
- Patient-Specific Haemodynamic Analysis of Virtual Grafting Strategies in Type-B Aortic Dissection: Impact of Compliance Mismatch.Cardiovascular engineering and technology · 2024Article
- Assessing pressure wave components for aortic stiffness monitoring through spectral regression learning.European heart journal open · 2024Article
- Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics.Bioengineering (Basel, Switzerland) · 2024Article
- Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system.American journal of physiology. Heart and circulatory physiology · 2023Article
- On the Longitudinal Wave Pumping in Fluid-filled Compliant Tubes.Physics of fluids (Woodbury, N.Y. : 1994) · 2023Article
- Non-Invasive Pressure-Only Aortic Wave Intensity Evaluation Using Hybrid Fourier Decomposition-Machine Learning Approach.IEEE transactions on bio-medical engineering · 2023Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Thoracic endovascular aortic repair (TEVAR) is a commonly performed operation for patients with type B aortic dissection (TBAD). The goal of TEVAR is to cover the proximal entry tear between the true lumen (TL) and the false lumen (FL) with an endograft to induce FL thrombosis, allow for aortic healing, and decrease the risk of aortic aneurysm and rupture. While TEVAR has shown promising outcomes, it can also result in devastating complications including stroke, spinal cord ischemia resulting in paralysis, as well as long-term heart failure, so treatment remains controversial. Similarly, the biomechanical impact of aortic endograft implantation and the hemodynamic impact of endograft design parameters such as length are not well-understood. In this study, a fluid-structure interaction (FSI) computational fluid dynamics (CFD) approach was used based on the immersed boundary and Lattice-Boltzmann method to investigate the association between the endograft length and hemodynamic variables inside the TL and FL. The physiological accuracy of the model was evaluated by comparing simulation results with the true pressure waveform measurements taken during a live TEVAR operation for TBAD. The results demonstrate a non-linear trend towards increased FL flow reversal as the endograft length increases but also increased left ventricular pulsatile workload. These findings suggest a medium-length endograft may be optimal by achieving FL flow reversal and thus FL thrombosis, while minimizing the extra load on the left ventricle. These results also verify that a reduction in heart rate with medical therapy contributes favorably to FL flow reversal.
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