ArticleMaterials today. Bio2022
Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold.
Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Ultra-thin elastin-based membranes as an innovative dressing to enhance skin wound healing.Materials today. Bio · 2026Article
- Research Progress on the Application of Novel Wound Healing Dressings in Different Stages of Wound Healing.Pharmaceutics · 2025Review
- Antibacterial Electrospun Membrane with Hierarchical Bead-on-String Structured Fibres for Wound Infections.Nanomaterials (Basel, Switzerland) · 2024Article
- Study of mechanical property and biocompatibility of graphene oxide/MEOBiomedical engineering letters · 2024Article
- Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing.Pharmaceutics · 2023Review
- Recent progress of antibacterial hydrogels in wound dressings.Materials today. Bio · 2023Review
- Hydrogel-Inducing Graphene-Oxide-Derived Core-Shell Fiber Composite for Antibacterial Wound Dressing.International journal of molecular sciences · 2023Article
- Micropatterned composite membrane guides oriented cell growth and vascularization for accelerating wound healing.Regenerative biomaterials · 2023Article
- Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications.Materials today. Bio · 2022Review
- Formulation of Magneto-Responsive Hydrogels from Dually Cross-Linked Polysaccharides: Synthesis, Tuning and Evaluation of Rheological Properties.International journal of molecular sciences · 2022Article
- Nanotechnology applications in oral pathology: A scoping review.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ideal artificial tissue scaffolds should provide an in vitro microenvironment comparable to native human skin tissue to direct cell functions, regulate tissue homeostasis, and promote tissue regeneration. A sandwich-like composite scaffold consisting of a hydrogel layer and two aligned nanofibre layers was fabricated and applied as a wound-healing dressing. Gentamicin was preloaded into the hydrogel middle layer and naturally released for antibacterial activity during the healing period. Nanofibrous layers embedded on the top and bottom surfaces of the hydrogel improved the tensile strength fivefold (1560 kPa and 465% strain) while serving as a diffusion barrier to reduce the gentamicin initial burst release (30%-15%). Inspired by the extracellular matrix (ECM), the surface of nanofibre top layer was patterned with triangular microarrays using micro-moulding approach to reflect the multidimensional structure of ECM. Biocompatibility of the scaffold is proven from cytotoxicity and haemolysis studies. Fibroblast cells revealed a highly elongated and consistent alignment modulated by the micropatterned fibrous layer and directed their migration towards the wound area. Excisional wounds treated with the scaffold promoted 97.49% wound closure with low inflammation and rapid re-epithelialization and angiogenesis. This scaffold, with its tailored functionality capable of accelerating wound healing, has high potential in tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.