Evidence map›Paper›PMID 35813977›Full record

ArticleClinical and translational allergy2022

Complex IgE sensitization patterns in ragweed allergic patients: Implications for diagnosis and specific immunotherapy.

Maria-Roxana Buzan, Lauriana-Eunice Zbîrcea, Pia Gattinger, Elijahu Babaev, Frank Stolz, Rudolf Valenta, Virgil Păunescu, Carmen Panaitescu, Kuan-Wei Chen

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Therapeutic peptides and proteins: Status and developments in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
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  12. [Sensitization characteristics of ragweed pollen in Beijing area].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
  13. Article
  14. Prospective assessment of pre-existing andFrontiers in immunology · 2023
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Maria-Roxana BuzanCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania.ORCID https://orcid.org/0000-0001-5030-3235
Lauriana-Eunice ZbîrceaCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania.ORCID https://orcid.org/0000-0003-1582-7740
Pia GattingerDepartment of Pathophysiology and Allergy Research, Division of Immunopathology, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria.ORCID https://orcid.org/0000-0001-6724-8543
Elijahu BabaevBiomay AG Vienna Competence Center Vienna Austria.
Frank StolzBiomay AG Vienna Competence Center Vienna Austria.
Rudolf ValentaDepartment of Pathophysiology and Allergy Research, Division of Immunopathology, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria.ORCID https://orcid.org/0000-0001-5944-3365
Virgil PăunescuCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania.
Carmen PanaitescuCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania.ORCID https://orcid.org/0000-0001-8749-9972
Kuan-Wei ChenOncoGen Center Pius Brinzeu County Clinical Emergency Hospital Timisoara Romania.ORCID https://orcid.org/0000-0001-5899-5766
Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara · ROBiomay (Austria) · ATMedical University of Vienna · ATSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ragweed ( Methods: IgE sensitization profiles from clinically well-characterized ragweed allergic patients ( Results: By IgE-immunoblotting 19 different IgE reactivity patterns with and without Amb a 1-sensitization were found. The majority of patients (>95%) suffered from rhino-conjunctivitis, around 60% reported asthma-like symptoms and about 25% had skin reactions. Patients with complex IgE sensitization profiles tended to have more clinical symptoms. Serum with and without Amb a 1-specific IgE induced basophil activation. Conclusions: Ragweed pollen allergic patients exhibit complex IgE reactivity profiles to ragweed allergens including Amb a 1 isoforms and cross-reactive carbohydrates indicating the importance of Amb a 1 isoforms and additional allergens for diagnosis and allergen-specific immunotherapy of ragweed allergy.

Indexed as

allergy diagnosiscross‐reactive carbohydrate determinantsIgE reactivityragweed allergysensitization profile

Identifiers

PMID35813977
PMCPMC9254219
OpenAlexW4283808193

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.