ArticleFrontiers in aging neuroscience2022
Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Investigation of cerebellar structure and static and dynamic functional connectivity in cervical spondylotic myelopathy patients.Neuroradiology · 2026Article
- Microstate-Specific Cross-Frequency Coupling Networks: A Spatiotemporal Framework for MCI Identification.CNS neuroscience & therapeutics · 2026Article
- Article
- Menopause-related brain fog as a midlife window in women's brain aging: toward ecologically valid measurement and digital phenotyping.Frontiers in human neuroscience · 2026Article
- Acute taVNS modulates lateralized hypoactivity in the right cerebral hemisphere in individuals with subjective cognitive decline.Frontiers in neuroscience · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Altered intra- and inter-network functional connectivity in pituitary adenomas with chiasmal compression.Quantitative imaging in medicine and surgery · 2025Article
- Topological and geometric signatures of brain network dynamics in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Effect of APOE ε4 Allele on Dynamic Local Spontaneous Brain Activity and Functional Integration in Alzheimer's Disease.Human brain mapping · 2025Article
- The balance between integration and segregation drives network dynamics maximizing multistability and metastability.Scientific reports · 2025Article
- Hyperbolic Graph Embedding of MEG Brain Networks to Study Brain Alterations in Individuals With Subjective Cognitive Decline.IEEE journal of biomedical and health informatics · 2024Article
- Differential neuropsychiatric associations of plasma biomarkers in older adults with major depression and subjective cognitive decline.Translational psychiatry · 2024Article
- Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Neurophysiological markers of early cognitive decline in older adults: a mini-review of electroencephalography studies for precursors of dementia.Frontiers in aging neuroscience · 2024Review
- Hyperbolic graph embedding of MEG brain networks to study brain alterations in individuals with subjective cognitive decline.bioRxiv : the preprint server for biology · 2023Article
- Disrupted basal forebrain-cortical connectivity in amnestic mild cognitive impairment: unveiling circuit-level links to cognitive decline.Frontiers in neurologyArticle
- Personalized modeling of Alzheimer's disease progression estimates neurodegeneration severity from EEG recordings.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- The Inverted U: Exploring the Interconnectedness of Movement and Cognitive Function Across the Lifespan.Wiley interdisciplinary reviews. Cognitive scienceReview
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Subjective cognitive decline (SCD) appears in the preclinical stage of the Alzheimer's disease continuum. In this stage, dynamic features are more sensitive than static features to reflect early subtle changes in functional brain connectivity. Therefore, we studied local and extended dynamic connectivity of the resting brain of people with SCD to determine their intrinsic brain changes. Methods: We enrolled cognitively normal older adults from the communities and divided them into SCD and normal control (NC) groups. We used mean dynamic amplitude of low-frequency fluctuation (mdALFF) to evaluate region of interest (ROI)-wise local dynamic connectivity of resting-state functional MRI. The dynamic functional connectivity (dFC) between ROIs was tested by whole-brain-based statistics. Results: When comparing SCD ( Conclusion: The local dynamic connectivity of SCD decreased in brain regions of cognitive executive control. Meanwhile, compensatory visual efforts and bottom-up attention rose. Mixed decrease and compensatory increase of dynamics of intrinsic brain activity suggest the transitional nature of SCD. The FPN local dynamics balance subjective and objective cognition and maintain cognitive preservation in preclinical dementia. Aberrant triple network model features the dFC alternations of SCD. Finally, the right lateralization phenomenon emerged early in the dementia continuum and affected local dynamic connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.