Evidence map›Paper›PMID 35813881›Full record

ArticleBrain communications2022

Vessel wall magnetic resonance and arterial spin labelling imaging in the management of presumed inflammatory intracranial arterial vasculopathy.

L A Benjamin, E Lim, M Sokolska, J Markus, T Zaletel, V Aggarwal, R Luder, E Sanchez, K Brown, R Sofat and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

L A BenjaminComprehensive Stroke Service, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, Box 16, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-9685-1664
E LimDepartment of Imaging, University College London Hospitals NHS foundation trust, London, NW1 2PG, UK.
M SokolskaDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, NW1 2PG, UK.
J MarkusDepartment of Imaging, University College London Hospitals NHS foundation trust, London, NW1 2PG, UK.
T ZaletelDepartment of Medicine, University of Cambridge, Cambridge, CB2 1TN, UK.
V AggarwalComprehensive Stroke Service, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, Box 16, London WC1N 3BG, UK.
R LuderDepartment of Medicine, North Middlesex University Hospital, London, N18 1QX, UK.
E SanchezDepartment of clinical virology, University College London Hospitals NHS Foundation Trust, London, NW1 2PG, UK.
K BrownDepartment of Virology, UK Health Security Agency, London, NW9 5EQ, UK.
R SofatDepartment of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 7BE, UK.
A SinghDepartment of Medicine, Royal Free Hospital Foundation Trust, London, NW3 2QG, UK.
C HoulihanDepartment of clinical virology, University College London Hospitals NHS Foundation Trust, London, NW1 2PG, UK.
E NastouliDepartment of clinical virology, University College London Hospitals NHS Foundation Trust, London, NW1 2PG, UK.
N LosseffComprehensive Stroke Service, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, Box 16, London WC1N 3BG, UK.
D J WerringComprehensive Stroke Service, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, Box 16, London WC1N 3BG, UK.
M M BrownStroke Research Centre, UCL Queen Square Institute of Neurology, University College London, London WC1B 5EH, UK.
J C MasonDepartment of Medicine, Hammersmith Hospital, London, W12 0HS, UK.
R J SimisterComprehensive Stroke Service, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, Box 16, London WC1N 3BG, UK.
H R JägerStroke Research Centre, UCL Queen Square Institute of Neurology, University College London, London WC1B 5EH, UK.
University College London Hospitals NHS Foundation Trust · GBHammersmith Hospital · GBNational Hospital for Neurology and Neurosurgery · GBNorth Middlesex Hospital · GBRoyal Free London NHS Foundation Trust · GBUK Health Security Agency · GBUniversity of Cambridge · GBUniversity of Liverpool · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Optimal criteria for diagnosing and monitoring response to treatment for infectious and inflammatory medium-large vessel intracranial vasculitis presenting with stroke are lacking. We integrated intracranial vessel wall MRI with arterial spin labelling into our routine clinical stroke pathway to detect presumed inflammatory intracranial arterial vasculopathy, and monitor disease activity, in patients with clinical stroke syndromes. We used predefined standardized radiological criteria to define vessel wall enhancement, and all imaging findings were rated blinded to clinical details. Between 2017 and 2018, stroke or transient ischaemic attack patients were first screened in our vascular radiology meeting and followed up in a dedicated specialist stroke clinic if a diagnosis of medium-large inflammatory intracranial arterial vasculopathy was radiologically confirmed. Treatment was determined and monitored by a multi-disciplinary team. In this case series, 11 patients were managed in this period from the cohort of young stroke presenters (<55 years). The median age was 36 years (interquartile range: 33,50), of which 8 of 11 (73%) were female. Two of 11 (18%) had herpes virus infection confirmed by viral nucleic acid in the cerebrospinal fluid. We showed improvement in cerebral perfusion at 1 year using an arterial spin labelling sequence in patients taking immunosuppressive therapy for >4 weeks compared with those not receiving therapy [6 (100%) versus 2 (40%)

Indexed as

ASLcerebral vasculitisneuroinflammationstrokevessel wall MR

Identifiers

PMID35813881
PMCPMC9263889
OpenAlexW4283166378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.