Evidence map›Paper›PMID 35813375›Full record

ArticleFrontiers in pediatrics2022

Specifically Increased Rate of Infections in Children Post Measles in a High Resource Setting.

Daniel Bühl, Olga Staudacher, Sabine Santibanez, Rainer Rossi, Hermann Girschick, Volker Stephan, Beatrix Schmidt, Patrick Hundsdoerfer, Arpad von Moers, Michael Lange and 6 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 14 institutions in 2 countries.

Daniel BühlDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Olga StaudacherDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Sabine SantibanezNational Reference Center for Measles, Mumps, Rubella, Robert Koch Institute, Berlin, Germany.
Rainer RossiDepartment of Pediatrics, Vivantes Klinikum Neukölln, Berlin, Germany.
Hermann GirschickChildren's Hospital, Vivantes Klinikum im Friedrichshain, Berlin, Germany.
Volker StephanDepartment of Pediatrics, Sana Klinikum Lichtenberg, Berlin, Germany.
Beatrix SchmidtSt. Joseph's Center for Pediatric and Adolescent Medicine, St. Joseph Krankenhaus, Berlin, Germany.
Patrick HundsdoerferDepartment of Pediatric and Adolescent Medicine, Helios-Klinikum Berlin-Buch, Berlin, Germany.
Arpad von MoersDepartment of Pediatrics and Neuropediatrics, DRK Kliniken Berlin Westend, Berlin, Germany.
Michael LangeDepartment of Pediatrics, Evangelisches Waldkrankenhaus Spandau, Berlin, Germany.
Michael BarkerDepartment of Pediatrics, Helios Klinikum Emil von Behring, Berlin, Germany.
Marcus A MallDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Ulrich HeiningerInfectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
Dorothea Matysiak-KloseDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch Institute, Berlin, Germany.
Annette MankertzNational Reference Center for Measles, Mumps, Rubella, Robert Koch Institute, Berlin, Germany.
Horst von BernuthDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Robert Koch Institute · DEBerlin-Brandenburger Centrum für Regenerative Therapien · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DECharité - Universitätsmedizin Berlin · DEDRK Kliniken Berlin · DEFreie Universität Berlin · DEHelios Hospital Berlin-Buch · DEHelios Klinikum Emil von Behring · DEKlinikum im Friedrichshain · DESana Klinikum Lichtenberg · DESt. Joseph-Krankenhaus · DEUniversity Children’s Hospital Basel · CHVivantes Klinikum · DEWaldkrankenhaus Protestant Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Post-measles increased susceptibility to subsequent infections seems particularly relevant in low-resource settings. We tested the hypothesis that measles causes a specifically increased rate of infections in children, also in a high-resource setting. Methods: We conducted a retrospective cohort study on a large measles outbreak in Berlin, Germany. All children with measles who presented to hospitals in Berlin were included as cases, children with non-infectious and children with non-measles infectious diseases as controls. Repeat visits within 3 years after the outbreak were recorded. Results: We included 250 cases, 502 non-infectious, and 498 infectious disease controls. The relative risk for cases for the diagnosis of an infectious disease upon a repeat visit was 1.6 (95% CI 1.4-2.0, Conclusion: Our study demonstrates for the first time in a high-resource setting, that increased post-measles susceptibility to subsequent infections in children is measles-specific-even compared to controls with previous non-measles infections.

Indexed as

Europehigh resource settingimmune amnesiameaslesoutbreak

Identifiers

PMID35813375
PMCPMC9261986
OpenAlexW4281759210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.