Evidence map›Paper›PMID 35813356›Full record

ReviewGynecologic oncology reports2022

Optimizing treatment selection and sequencing decisions for first-line maintenance therapy of newly diagnosed advanced ovarian cancer.

Jeffrey C H Goh, Charlie Gourley, David S P Tan, Angélica Nogueira-Rodrigues, Hesham Elghazaly, Marc Edy Pierre, Gonzalo Giornelli, Byoung-Gie Kim, Flavia Morales-Vasquez, Alexandra Tyulyandina

Open access · goldAbstract readReview
In one paragraph

Review in Gynecologic oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Observational
  3. Advances in Systemic Therapy for Ovarian Cancer Over the Past Decade: A Clinical and Molecular Perspective.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Physician-reported patient involvement and treatment decisions in first-line ovarian cancer in the USA and Europe.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 9 countries.

Jeffrey C H GohDepartment of Oncology - Cancer Care Services, Level 5, Joyce Tweddell Building, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Queensland 4029, University of Queensland, St Lucia, Australia.
Charlie GourleyEdinburgh Cancer Research UK Centre, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road South Edinburgh, EH4 2XR, UK.
David S P TanDepartment of Haematology-Oncology, National University Cancer Institute, Singapore.
Angélica Nogueira-RodriguesFederal University of Minas Gerais, DOM Oncologia, Grupo Oncoclınicas, EVA Brazilian Group of Gynecologic Cancer, LACOG, Porto Alegre, Brazil.
Hesham ElghazalyClinical Oncology Head of Medical Research Center MASRI, Ain Shams University, Cairo, Egypt.
Marc Edy PierreGynecology Oncology Unit, Luis Carlos Samiento Angulo Cancer Treatment and Research Center - CTIC,Bogotá, Colombia.
Gonzalo GiornelliDepartment of Oncology, Instituto Alexander Fleming, Buenos Aires, Argentina.
Byoung-Gie KimDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Flavia Morales-VasquezDepartment of Medical Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico.
Alexandra TyulyandinaDepartment of Clinical Pharmacology And Chemotherapy, N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
Ain Shams University · EGInstituto Alexander Fleming · ARInstituto Nacional de Cancerología · MXNational University Cancer Institute, Singapore · SGRussian Cancer Research Center NN Blokhin · RUSamsung Medical Center · KRUniversidade Federal de Minas Gerais · BRUniversity of Queensland · AUWestern General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence and mortality rates of ovarian cancer are increasing globally. Ovarian cancer is diagnosed at an advanced stage in 80% of women. After standard, platinum-based, front-line chemotherapy, poly (ADP-ribose) polymerase (PARP) inhibitors and antiangiogenic agents are successfully employed as maintenance strategies for newly diagnosed, advanced ovarian cancer patients. Landmark clinical studies, including SOLO-1, PAOLA-1, PRIMA, and VELIA, have provided crucial insights on optimizing first-line maintenance treatment using PARP inhibitors. A group of ovarian cancer experts, primarily from low- and middle-income countries, met in September 2019 to discuss new developments for the first-line treatment of ovarian cancer and its implications. Key implications of the evolving clinical data included: (1) olaparib or niraparib maintenance therapy appears to be the preferred choice for patients with

Indexed as

BRCA mutationsGenetic testingOlaparibOvarian cáncerPARP inhibitors

Identifiers

PMID35813356
PMCPMC9263863
OpenAlexW4283025800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.