Evidence map›Paper›PMID 35813269›Full record

ReviewFrontiers in systems neuroscience2022

Functional Connectivity of the Chemosenses: A Review.

Michael C Farruggia, Robert Pellegrino, Dustin Scheinost

Abstract readReview
In one paragraph

Review in Frontiers in systems neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Prediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael C FarruggiaInterdepartmental Neuroscience Program, Yale University, New Haven, CT, United States.
Robert PellegrinoMonell Chemical Senses Center, Philadelphia, PA, United States.
Dustin ScheinostInterdepartmental Neuroscience Program, Yale University, New Haven, CT, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
INTERDISCIPLINARY TRAINING IN THE CHEMICAL SENSEST32DC000014 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI PAMELA HELEN DALTON, Joel D Mainland · 1989 to 2026
$6.2M
Biophysical models of human olfactory intensity perceptionF32DC020380 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI PELLEGRINO, ROBERT · 2022 to 2023
$111k
NCATS NIH HHS UL1 TR001863NIDCD NIH HHS F32 DC020380NIDCD NIH HHS T32 DC000014
6 · The paper itself

Abstract

Functional connectivity approaches have long been used in cognitive neuroscience to establish pathways of communication between and among brain regions. However, the use of these analyses to better understand how the brain processes chemosensory information remains nascent. In this review, we conduct a literature search of all functional connectivity papers of olfaction, gustation, and chemesthesis, with 103 articles discovered in total. These publications largely use approaches of seed-based functional connectivity and psychophysiological interactions, as well as effective connectivity approaches such as Granger Causality, Dynamic Causal Modeling, and Structural Equation Modeling. Regardless of modality, studies largely focus on elucidating neural correlates of stimulus qualities such as identity, pleasantness, and intensity, with task-based paradigms most frequently implemented. We call for further "model free" or data-driven approaches in predictive modeling to craft brain-behavior relationships that are free from

Indexed as

chemesthesischemical sensesfMRIfunctional connectivitygustationolfactionsmelltaste

Identifiers

PMID35813269
PMCPMC9257046

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.