Evidence map›Paper›PMID 35812821›Full record

ArticleContemporary clinical trials communications2022

Protocol for mindfulness-oriented recovery enhancement (MORE) in the management of lumbosacral radiculopathy/radiculitis symptoms: A randomized controlled trial.

Ryan S Wexler, Devon J Fox, Hannah Edmond, Johnny Lemau, Danielle ZuZero, Melissa Bollen, Diane Montenegro, Anand Parikshak, Austin R Thompson, Nels L Carlson and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ryan S WexlerHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Devon J FoxHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Hannah EdmondHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Johnny LemauHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Danielle ZuZeroHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Melissa BollenHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Diane MontenegroHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Anand ParikshakHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Austin R ThompsonDepartment of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA.
Nels L CarlsonDepartment of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA.
Hans L CarlsonDepartment of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA.
Anna E WentzHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Ryan BradleyHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Douglas A HanesHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Heather ZwickeyHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Courtney K PickworthHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.

Funding

Building Research across Interdisciplinary Gaps (BRIDG) R90 Training Program - Administrative SupplementR90AT008924 · NCCIH · NATIONAL UNIVERSITY OF NATURAL MEDICINE · PI BRADLEY, RYAN D, ZWICKEY, HEATHER LEA · 2015 to 2025
$5.2M
Mentorship in Clinical Complementary and Integrative Health ResearchK24AT011568 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRADLEY, RYAN D · 2021 to 2025
$762k
NCCIH NIH HHS K24 AT011568NCCIH NIH HHS R90 AT008924
6 · The paper itself

Abstract

Introduction: Lumbosacral radiculopathy/radiculitis (LR) or "sciatica" is a commonly intractable sequelae of chronic low back pain (LBP), and challenges in the treatment of LR indicate that persistent pain may have both mechanical and neuropathic origins. Mindfulness-based interventions have been demonstrated to be effective tools in mitigating self-reported pain in LBP patients. This paper describes the protocol for a randomized controlled trial (RCT) evaluating the effects of the specific mindfulness-based intervention Mindfulness-Oriented Recovery Enhancement (MORE) on LR symptoms and sequelae, including mental health and physical function. Methods: Participants recruited from the Portland, OR area are screened before completing a baseline visit that includes a series of self-report questionnaires and surface electromyography (sEMG) of the lower extremity. Upon enrollment, participants are randomly assigned to the MORE (experimental) group or treatment as usual (control) group for 8 weeks. Self-reported assessments and sEMG studies are repeated after the intervention is complete for pre/post-intervention comparisons. The outcome measures evaluate self-reported pain, physical function, quality of life, depression symptoms, trait mindfulness, and reinterpretation of pain, with surface electromyography (sEMG) findings evaluating objective physical function in patients with LR. To our knowledge, this is the first trial to date using an objective measure, sEMG, to evaluate the effects of a mindfulness-based intervention on LR symptoms. Hypotheses: We hypothesize that MORE will be effective in improving self-reported pain, physical function, quality of life, depression symptoms, mindfulness, and reinterpretation of pain scores after 8 weeks of mindfulness training as compared to treatment as usual. Additionally, we hypothesize that individuals in the MORE group with abnormal sEMG findings at baseline will have improved sEMG findings at their 8-week follow-up visit.

Indexed as

Low back painLumbosacral radiculopathyMindfulnessMindfulness-oriented recovery enhancementRCT protocolVirtual intervention

Identifiers

PMID35812821
PMCPMC9260614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.