Evidence map›Paper›PMID 35812423›Full record

ArticleFrontiers in immunology2022

Exosomally Targeting microRNA23a Ameliorates Microvascular Endothelial Barrier Dysfunction Following Rickettsial Infection.

Changcheng Zhou, Jiani Bei, Yuan Qiu, Qing Chang, Emmanuel Nyong, Nikos Vasilakis, Jun Yang, Balaji Krishnan, Kamil Khanipov, Yang Jin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Changcheng ZhouDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Jiani BeiDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Yuan QiuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Qing ChangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Emmanuel NyongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Nikos VasilakisDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Jun YangDepartment of Internal Medicine, Endocrinology, University of Texas Medical Branch, Galveston, TX, United States.
Balaji KrishnanMitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX, United States.
Kamil KhanipovDepartment of Pharmacology, University of Texas Medical Branch, Galveston, TX, United States.
Yang JinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, Boston, MA, United States.
Xiang FangMitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX, United States.
Angelo GaitasThe Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Bin GongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
The University of Texas Medical Branch at Galveston · USBoston Medical Center · USIcahn School of Medicine at Mount Sinai · US

Funding

LncRNA regulates lung inflammationR01HL142758 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2019 to 2022
$2.0M
Epac1 Plays a Critical Role in Bacterial Adhesion during RickettsiosesR01AI121012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2016 to 2020
$1.9M
Development of the RNA molecule-enriched, cell type-specific exosomesR33AI121644 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2018 to 2020
$1.4M
Mechanistic insights of inflammation and organ failure after trauma or critical illnessR01GM127596 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2018 to 2021
$1.3M
Targeting the Host Adenosine A2A Receptor to Protect Against Fatal Rickettsiosis Using an Approved Parkinson's Disease DrugR21AI137785 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2018 to 2019
$440k
The role of IL-1 family of cytokines in tick-transmitted ehrlichiosisR21AI144328 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2019 to 2020
$435k
Targeting extracellular tRNA-derived RNA fragments (tRFs) to protect against fatal rickettsiosisR21AI154211 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2020 to 2021
$435k
Inflammasome activation and ehrlichial dissemination in tick vs needle transmissionR03AI142406 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2019 to 2020
$158k
NHLBI NIH HHS R01 HL142758NIAID NIH HHS R01 AI121012NIAID NIH HHS R03 AI142406NIAID NIH HHS R21 AI137785NIAID NIH HHS R21 AI144328NIAID NIH HHS R21 AI154211NIAID NIH HHS R33 AI121644NIGMS NIH HHS R01 GM127596
6 · The paper itself

Abstract

Spotted fever group rickettsioses caused by

Indexed as

ExosomesRickettsiaRickettsia InfectionsVascular DiseasesBrainEndothelial CellsHumansMicroRNAsMicroRNAsMIRN23a microRNA, humanendothelial barrier dysfunctionexosomefluidic AFMmicroRNARickettsiasingle living cell model

Identifiers

PMID35812423
PMCPMC9260018
OpenAlexW4283370419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.