Evidence map›Paper›PMID 35812387›Full record

ArticleFrontiers in immunology2022

Identification of Highly Cross-Reactive Mimotopes for a Public T Cell Response in Murine Melanoma.

Beth E Grace, Coralie M Backlund, Duncan M Morgan, Byong H Kang, Nishant K Singh, Brooke D Huisman, C Garrett Rappazzo, Kelly D Moynihan, Laura Maiorino, Connor S Dobson and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Beth E GraceDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Coralie M BacklundDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Duncan M MorganKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Byong H KangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Nishant K SinghDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Brooke D HuismanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
C Garrett RappazzoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Kelly D MoynihanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Laura MaiorinoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Connor S DobsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Taeyoon KyungDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Khloe S GordonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Patrick V HolecDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Overbeck C Takou MbahRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.
Daniel GarafolaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Shengwei WuKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
J Christopher LoveKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
K Dane WittrupDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Darrell J IrvineDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Michael E BirnbaumDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Massachusetts Institute of Technology · USRagon Institute of MGH, MIT and Harvard · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
Graduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6M
NCI NIH HHS P30 CA014051NIGMS NIH HHS T32 GM008334
6 · The paper itself

Abstract

While immune checkpoint blockade results in durable responses for some patients, many others have not experienced such benefits. These treatments rely upon reinvigorating specific T cell-antigen interactions. However, it is often unknown what antigens are being recognized by T cells or how to potently induce antigen-specific responses in a broadly applicable manner. Here, we characterized the CD8

Indexed as

CD8-Positive T-LymphocytesMelanomaAnimalsAntigens, NeoplasmCross ReactionsImmunotherapyMiceAntigens, Neoplasmantigenendogenous retrovirusmelanomamimotopeT cell receptor

Identifiers

PMID35812387
PMCPMC9260506
OpenAlexW4283331587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.