Evidence map›Paper›PMID 35812351›Full record

ReviewJournal of orthopaedics

Restricted kinematic alignment in primary total knee arthroplasty: A systematic review of radiographic and clinical data.

Salvatore Risitano, Giorgio Cacciola, Luigi Sabatini, Marcello Capella, Francesco Bosco, Fortunato Giustra, Alessandro Massè, Raju Vaishya

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06726993 (Comparison of Restricted Kinematic Alignment Versus Unrestricted Kinematic Alignment in Primary Total Knee Arthroplasty), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06726993 nanot yet recruitingnot on this map

Comparison of Restricted Kinematic Alignment Versus Unrestricted Kinematic Alignment in Primary Total Knee Arthroplasty:- Randomized Controlled Trial

TypeinterventionalSponsorAssiut UniversityRan2025 to 2027Enrolled80ConditionsOsteoarthritis (OA) of the Knee, Total Knee AnthroplastyArmsTotal knee arthroplasty
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Reduced knee laxity and failure rate following anterior cruciate ligament reconstruction compared with repair for acute tears: a meta-analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023
    Pooled it
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Salvatore RisitanoDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Giorgio CacciolaDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Luigi SabatiniDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Marcello CapellaDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Francesco BoscoDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Fortunato GiustraDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Alessandro MassèDepartment of Orthopaedics and Traumatology, University of Turin, CTO, Turin, Italy.
Raju VaishyaIndraprastha Apollo Hospitals, New Delhi, India.
University of Turin · ITIndraprastha Apollo Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Kinematic alignment (KA) has increased in popularity in recent years, becoming a viable alternative to MA with encouraging short- and mid-term follow-up results. Recently, the concept of restricted kinematic alignment (rKA) has been developed to restore native knee kinematics better, avoiding failure of coronal alignment. This systematic review aims to examine whether rKA improves outcome scores (PROMs) compared with MA and to evaluate the radiographic analysis of the lower limb alignment and the causes of complications and reoperations with the rKA approach. Methods: A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines on the Pubmed/Medline, Scopus, Cochrane Library, and Embase databases. The following key terms were used: "restricted kinematic alignment, rKA, kinematic alignment, primary total knee arthroplasty, primary total knee replacement, TKA rKA, and TKR rKA." The initial screening identified 328 studies. Each eligible article was evaluated according to the inclusion criteria: studies with levels of evidence (LoE) 1 to 4, written in English, published through May 2022, and involving human subjects. Criteria from the Methodological Index for Non-Randomized Studies (MINORS) were used to assess the methodological quality of the articles. Results: Six clinical studies were included in this systematic review. The study was registered in the International Prospective Registry of Systematic Reviews (PROSPERO). A total of 574 knees were included. After excluding patients due to loss of follow-up or missing data, 475 knees were analyzed. The following rKA-related data were evaluated: patient-reported outcome scores (PROMs), radiographic analysis of the lower limb alignment, and causes of complications and reoperations. Conclusions: The rKA is an improved concept for restoring native knee kinematics, avoiding excessive coronal varus/valgus alignment. It provides equivalent or slightly better PROMs than MA without increasing the risk of short-middle-term implant failure. Clinical studies with extended follow-up are needed to confirm this trend.

Indexed as

ArthroplastyKAKinematic alignmentKneeMechanical alignmentRestricted kinematic alignment

Identifiers

PMID35812351
PMCPMC9263746
OpenAlexW4283784369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.