Evidence map›Paper›PMID 35812318›Full record

ArticleFrontiers in physiology2022

eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury.

Saad Sammani, Tadeo Bermudez, Carrie L Kempf, Jin H Song, Justin C Fleming, Vivian Reyes Hernon, Matthew Hufford, Lin Tang, Hua Cai, Sara M Camp and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2025
    Article
  8. Predictive modeling of ARDS mortality integrating biomarker/cytokine, clinical and metabolomic data.Translational research : the journal of laboratory and clinical medicine · 2025
    Article
  9. Article
  10. Anti-DAMP therapies for acute inflammation.Frontiers in immunology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. An eNAMPT-neutralizing mAb reduces post-infarct myocardial fibrosis and left ventricular dysfunction.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Saad SammaniDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Tadeo BermudezDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Carrie L KempfDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Jin H SongDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Justin C FlemingDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Vivian Reyes HernonDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Matthew HuffordDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Lin TangDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Hua CaiDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States.
Sara M CampDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Viswanathan NatarajanDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Jeffrey R JacobsonDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Steven M DudekDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Diego R MartinDepartment of Radiology and the Translational Imaging Center, Houston Methodist Hospital and the Houston Methodist Research Institute, Houston, TX, United States.
Christof KarmonikDepartment of Radiology and the Translational Imaging Center, Houston Methodist Hospital and the Houston Methodist Research Institute, Houston, TX, United States.
Xiaoguang SunDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Belinda SunDepartment of Pathology, University of Arizona Health Sciences, Tucson, AZ, United States.
Nancy G CasanovaDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Christian BimeDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Joe G N GarciaDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
University of Arizona · USUniversity of Illinois Chicago · USHouston Methodist · USImaging Center · USUniversity of California, Los Angeles · US

Funding

Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia · 2016 to 2026
$24.4M
Angiotensin II Uncoupling of Enos in HypertensionR01HL077440 · NHLBI · UNIVERSITY OF CHICAGO · PI CAI, HUA LINDA · 2005 to 2019
$4.8M
NOXs, eNOS Uncoupling and Diabetic AtherogenesisR01HL088975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2010 to 2019
$4.5M
Targeting NOX4-dependent mitochondrial dysfunction, autophagy and defective calcium handling in AFR01HL162407 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, GOLDHABER, JOSHUA I · 2022 to 2025
$2.8M
Phenotypes and mechanisms of pulmonary hypertension-driven cognitive impairment and Alzheimer's diseaseR01HL154754 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, MAKINO, AYAKO · 2020 to 2023
$2.5M
Netrin-1 and Netrin-1 Preconditioned EPCs in Vascular ProtectionR01HL142951 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2020 to 2023
$2.0M
Novel Therapeutic Antibody Targeting of Extracellular NAMPT in Ventilator-Induced Lung Injury (VILI)R42HL145930 · NHLBI · AQUALUNG THERAPEUTICS CORP. · PI GARCIA, JOE G. N. · 2019 to 2021
$1.7M
SELPLG as a candidate gene in Acute Respiratory Distress SyndromeK08HL141623 · NHLBI · UNIVERSITY OF ARIZONA · PI BIME, CHRISTIAN · 2018 to 2022
$863k
NHLBI NIH HHS K08 HL141623NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL077440NHLBI NIH HHS R01 HL088975NHLBI NIH HHS R01 HL142951NHLBI NIH HHS R01 HL154754NHLBI NIH HHS R01 HL162407NHLBI NIH HHS R42 HL145930
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ARDSB-linesDAMPeNAMPTmAb

Identifiers

PMID35812318
PMCPMC9257134
OpenAlexW4283397238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.