Evidence map›Paper›PMID 35812302›Full record

ArticleKidney international reports2022

Biomarkers of Kidney Tubule Disease and Risk of End-Stage Kidney Disease in Persons With Diabetes and CKD.

Jonathan G Amatruda, Ronit Katz, Mark J Sarnak, Orlando M Gutierrez, Jason H Greenberg, Mary Cushman, Sushrut Waikar, Chirag R Parikh, Jeffrey R Schelling, Manasi P Jogalekar and 6 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 1 country.

Jonathan G AmatrudaDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Ronit KatzDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
Mark J SarnakDivision of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
Orlando M GutierrezDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jason H GreenbergSection of Nephrology, Department of Pediatrics, Clinical and Translational Research Accelerator, Yale University School of Medicine, New Haven, Connecticut, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Sushrut WaikarSection of Nephrology, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Chirag R ParikhDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jeffrey R SchellingDivision of Nephrology, Department of Internal Medicine, MetroHealth System, Cleveland, Ohio, USA.
Manasi P JogalekarDivision of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Joseph V BonventreDivision of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ramachandran S VasanDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Paul L KimmelNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Michael G ShlipakKidney Health Research Collaborative, San Francisco VA Medical Center and University of California, San Francisco, San Francisco, California, USA.
Joachim H IxDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
CKD Biomarkers Consortium
Brigham and Women's Hospital · USSan Francisco VA Medical Center · USBoston Medical Center · USBoston University · USJohns Hopkins University · USMetroHealth · USNational Institute of Diabetes and Digestive and Kidney Diseases · USTufts Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Vermont · USUniversity of Washington · USVA San Diego Healthcare System · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Mechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2M
Urinary Biomarkers of Chronic Kidney Disease Pathology and ProgressionU01DK085660 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, WAIKAR, SUSHRUT S. · 2009 to 2019
$5.3M
Beyond the Glomerulus: Novel Clinical Markers of Kidney Health and PrognosisU01DK102730 · NIDDK · TUFTS MEDICAL CENTER · PI GUTIERREZ, ORLANDO M, IX, JOACHIM H · 2016 to 2020
$1.9M
Mentored Patient Oriented Research in Kidney DiseaseK24DK110427 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2016 to 2020
$780k
NSAID Use and Multidimensional Assessment of Kidney HealthF32DK126381 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AMATRUDA, JONATHAN · 2020 to 2021
$153k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS F32 DK126381NIDDK NIH HHS K24 DK110427NIDDK NIH HHS R01 DK039773NIDDK NIH HHS U01 DK085660NIDDK NIH HHS U01 DK102730NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Introduction: Tubulointerstitial damage in diabetes and chronic kidney disease (CKD) is poorly captured by estimated glomerular filtration rate (eGFR) and albuminuria. Urine biomarkers of kidney health may better elucidate disease progression in persons with diabetes and CKD. Methods: Per case-cohort design, we randomly selected a subcohort of 560 study participants of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study from 1092 adults with diabetes and baseline eGFR <60 ml/min per 1.73 m Results: At baseline, subcohort participants had mean age of 70 ± 9 years, mean eGFR of 40 ±13 ml/min per 1.73 m Conclusion: Among adults with diabetes and eGFR <60 ml/min per 1.73 m

Indexed as

biomarkerschronic kidney diseasediabetes mellitusend-stage kidney disease

Identifiers

PMID35812302
PMCPMC9263389
OpenAlexW4224235325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.