Evidence map›Paper›PMID 35812246›Full record

ArticleJournal of immunology research2022

Methane Alleviates Lung Injury through the IL-10 Pathway by Increasing T Regulatory Cells in a Mouse Asthma Model.

Ying Yao, Xiaoyong Miao, Liping Wang, Zhengyu Jiang, Lingxia Li, Ping Jiang, Yifei Wang, Aixia Jin, Na Li, Changli Wang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Ying YaoDepartment of Anesthesiology, Navy Medical Center, Naval Military Medical University, Shanghai 200052, China.
Xiaoyong MiaoDepartment of Anesthesiology, Navy Medical Center, Naval Military Medical University, Shanghai 200052, China.
Liping WangDepartment of Anesthesiology, Fuzhou General Hospital of PLA, Fuzhou, China.
Zhengyu JiangDepartment of Anesthesiology, Navy Medical Center, Naval Military Medical University, Shanghai 200052, China.
Lingxia LiDepartment of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Ping JiangDepartment of Biochemistry and Psychopharmacology, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China.
Yifei WangDepartment of Anesthesiology, Navy Medical Center, Naval Military Medical University, Shanghai 200052, China.
Aixia JinDepartment of Anesthesiology, Navy Medical Center, Naval Military Medical University, Shanghai 200052, China.
Na LiDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Changli WangDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Kezhe TanDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yan MengDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Jinjun BianDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yan ZhangDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xiaoming DengDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Jianping CaoDepartment of Anesthesiology, Navy Medical Center, Naval Military Medical University, Shanghai 200052, China.ORCID https://orcid.org/0000-0002-9460-7895
Second Military Medical University · CNFuzhou General Hospital of Nanjing Military Command · CNShanghai Mental Health Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic asthma is associated with allergen-induced airway hyperresponsiveness and inflammatory cell infiltration. While moderate-to-severe asthma with refractory symptoms is difficult to treat, methane is protective against organ damage. In this study, an asthmatic mouse model was established. Airway resistance under acetylcholine stimulation in asthmatic mice and histology of lung tissue injury were determined. EOS infiltration was determined by flow cytometry. Enzyme-linked immunosorbent assays (ELISAs) were performed for the determination of relevant cytokine levels in asthmatic mice with or without methane treatment. The potential mechanisms of methane under anti-IL-10 antibody intraperitoneal intervention were assessed by ELISA and flow cytometry. Pulmonary T regulatory cells (Tregs) were analyzed by flow cytometry, and anti-CD25 antibody was used to block them. Immunoblot analysis was performed to evaluate if methane played a role in the asthmatic lungs via the NF-

Indexed as

AsthmaLung InjuryAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalLungMethaneMiceMice, Inbred BALB CNF-kappa BOvalbuminMethaneNF-kappa BOvalbumin

Identifiers

PMID35812246
PMCPMC9262571
OpenAlexW4283758720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.