Evidence map›Paper›PMID 35812239›Full record

ArticleFrontiers in neuroscience2022

The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep.

Brice V McConnell, Eugene Kronberg, Lindsey M Medenblik, Vitaly O Kheyfets, Alberto R Ramos, Stefan H Sillau, Rachelle L Pulver, Brianne M Bettcher

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  5. Article
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  7. Article
  8. Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brice V McConnellDepartment of Neurology, University of Colorado, Denver, Denver, CO, United States.
Eugene KronbergDepartment of Neurology, University of Colorado, Denver, Denver, CO, United States.
Lindsey M MedenblikDepartment of Neurology, University of Colorado, Denver, Denver, CO, United States.
Vitaly O KheyfetsPediatric Critical Care Medicine, University of Colorado, Denver, Denver, CO, United States.
Alberto R RamosDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
Stefan H SillauDepartment of Neurology, University of Colorado, Denver, Denver, CO, United States.
Rachelle L PulverDepartment of Neurology, University of Colorado, Denver, Denver, CO, United States.
Brianne M BettcherDepartment of Neurology, University of Colorado, Denver, Denver, CO, United States.

Funding

Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
BIOMETRIC-GENETIC ANALYSIS OF CARDIOVASCULAR DISEASET32HL007567 · NHLBI · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ZHU, XIAOFENG · 1985 to 2021
$6.0M
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive AgingR01AG058772 · NIA · UNIVERSITY OF COLORADO DENVER · PI BETTCHER, BRIANNE MAGOUIRK · 2019 to 2023
$3.7M
FAMILIAL AGGREGATION OF OBSTRUCTIVE SLEEP APNEAR01HL046380 · NHLBI · UNIVERSITY HOSPITALS OF CLEVELAND · PI REDLINE, SUSAN S · 1990 to 2005
$3.5M
NCRR NIH HHS M01 RR000080NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R24 HL114473NHLBI NIH HHS T32 HL007567NIA NIH HHS R01 AG058772
6 · The paper itself

Abstract

Slow wave activity (SWA) during sleep is associated with synaptic regulation and memory processing functions. Each cycle of non-rapid-eye-movement (NREM) sleep demonstrates a waxing and waning amount of SWA during the transitions between stages N2 and N3 sleep, and the deeper N3 sleep is associated with an increased density of SWA. Further, SWA is an amalgam of different types of slow waves, each identifiable by their temporal coupling to spindle subtypes with distinct physiological features. The objectives of this study were to better understand the neurobiological properties that distinguish different slow wave and spindle subtypes, and to examine the composition of SWA across cycles of NREM sleep. We further sought to explore changes in the composition of NREM cycles that occur among aging adults. To address these goals, we analyzed subsets of data from two well-characterized cohorts of healthy adults: (1) The DREAMS Subjects Database (

Indexed as

biomarkercouplingEEGmemorysleep spindleslow wave

Identifiers

PMID35812239
PMCPMC9260314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.