Evidence map›Paper›PMID 35812078›Full record

ArticleFASEB bioAdvances2022

ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation.

Justin M Wolter, Jessica A Jimenez, Jason L Stein, Mark J Zylka

Open access · goldAbstract read
In one paragraph

Article in FASEB bioAdvances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  2. Unusual Phospholipids fromJournal of the American Chemical Society · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Justin M WolterUNC Neuroscience Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Jessica A JimenezCurriculum in Toxicology & Environmental Medicine The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Jason L SteinUNC Neuroscience Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Mark J ZylkaUNC Neuroscience Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
University of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Environmental-use chemicals that target pathways linked to autism and other neurodevelopmental disordersR35ES028366 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark J. Zylka · 2019 to 2026
$6.8M
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R35 ES028366
6 · The paper itself

Abstract

Numerous autism spectrum disorder (ASD) risk genes are associated with Wnt signaling, suggesting that brain development may be especially sensitive to genetic perturbation of this pathway. Additionally, valproic acid, which modulates Wnt signaling, increases risk for ASD when taken during pregnancy. We previously found that an autism-linked gain-of-function

Indexed as

diethanolamineneural progenitor cellsToxCastWnt signaling

Identifiers

PMID35812078
PMCPMC9254222
OpenAlexW4220922554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.